The activation of TLR4-MyD88 signaling promotes hepatic dysfunction and fibrotic changes in SD rats resulting from prolonged exposure to sodium arsenite

Q Song, Y Jin, R He, L Fan, C Tu, X Chen… - International …, 2024 - Elsevier
Arsenic, a poisonous metalloid element, is linked to liver diseases, but the exact
mechanisms for this process are not yet to be completely elucidated. Toll like receptor 4 …

Calcitriol Inhibits NaAsO2 Triggered Hepatic Stellate Cells Activation and Extracellular Matrix Oversecretion by Activating Nrf2 Signaling Pathway Through Vitamin D …

D Wang, R He, Q Song, H Diao, Y Jin… - Biological trace element …, 2024 - Springer
Previous studies, including our own, have demonstrated that arsenic exposure can induce
liver fibrosis, while the underlying mechanism remains unclear and there is currently no …

[HTML][HTML] Artesunate Induces Ferroptosis in Hepatic Stellate Cells and Alleviates Liver Fibrosis via the ROCK1/ATF3 Axis

Y Wang, Y Li, Y Qiu, M Shen, L Wang… - Journal of Clinical …, 2024 - ncbi.nlm.nih.gov
Methods HSC activation and ferroptosis were studied in vitro by western blotting,
polymerase chain reaction, immunofluorescence, and other assays. ATF3 electrophoretic …

Oral arsenite exposure induces inflammation and apoptosis in pulmonary tissue: acute and chronic evaluation in young and adult mice

S Pradhan, SA Ali, M Rachamalla, S Niyogi… - BioMetals, 2024 - Springer
Inorganic arsenic is a well-known environmental toxicant, and exposure to this metalloid is
strongly linked with severe and extensive toxic effects in various organs including the lungs …

Conditional deletion of CEACAM1 in hepatic stellate cells causes their activation

HT Muturi, HE Ghadieh, S Asalla, SG Lester… - Molecular …, 2024 - Elsevier
Objectives Hepatic CEACAM1 expression declines with advanced hepatic fibrosis stage in
patients with metabolic dysfunction-associated steatohepatitis (MASH). Global and …

[HTML][HTML] Role of SESTRIN2/AMPK/ULK1 pathway activation and lysosomes dysfunction in NaAsO2-induced liver injury under oxidative stress

D Bi, D Zheng, M Shi, Q Hu, H Wang, H Zhi… - Ecotoxicology and …, 2023 - Elsevier
Arsenic, a serious environmental poison to human health, is widely distributed in nature. As
the main organ of arsenic metabolism, liver is easily damaged. In the present study, we …

Prolonged exposure to NaAsO2 induces thyroid dysfunction and inflammatory injury in Sprague‒Dawley rats, involvement of NLRP3 inflammasome‒mediated …

L Fan, Q Song, Y Jin, R He, H Diao, P Luo… - Archives of …, 2024 - Springer
Arsenic, a well-known hazardous toxicant, has been found in recent years to act as an
environmental endocrine disruptor that accumulates in various endocrine organs, impeding …

[HTML][HTML] Nod-like receptor protein 3 inflammasome-mediated pyroptosis contributes to chronic NaAsO2 exposure-induced fibrotic changes and dysfunction in the liver …

Y Jin, Q Song, R He, H Diao, H Gaoyang… - Ecotoxicology and …, 2024 - Elsevier
The metalloid arsenic, known for its toxic properties, is widespread presence in the
environment. Our previous research has confirmed that prolonged exposure to arsenic can …

[HTML][HTML] Alterations of Bax/Bcl-2 ratio contribute to NaAsO2 induced thyrotoxicity in human thyroid follicular epithelial cells and SD rats

L Fan, Z He, L Wang, H Gaoyang, D Wang… - … and Environmental Safety, 2023 - Elsevier
The environmental toxicant arsenic causes various human diseases and threatens millions
of people worldwide. Recently, a limited number of studies have revealed that exposure to …

Resveratrol Alleviates Arsenic Exposure-Induced Liver Fibrosis in Rats by Inhibiting Hepatocyte Senescence

Q Ran, D Song, Q Wang, D Wang, X Chen… - … Trace Element Research, 2024 - Springer
Arsenic is an environmental pollutant that has garnered considerable attention from the
World Health Organization. Liver fibrosis is an advanced pathological stage of liver injury …