Epithelial cells of the gastrointestinal tract are an important barrier between the “milieu
interne” and the luminal content of the gut. They perform transport of nutrients, salts, and …

SLC26A9 is a member of the SLC26 family of anion transporters, which is expressed at high
levels in airway and gastric surface epithelial cells. The transport properties and regulation …

The fungicide imazalil (IMZ) is widely used to prevent and treat fungal diseases in plants and
animals. Here, male adult C57BL/6 mice were exposed to 0.1, 0.5, and 2.5 mg/kg body …

The cystic fibrosis transmembrane conductance regulator (CFTR) is an anion channel
regulated by cAMP‐dependent phosphorylation, which is expressed in epithelial cells of a …

We have shown elsewhere that acidification is an early event in apoptosis, preceding DNA
cleavage. Cells expressing the most common mutation (delF508) of the cystic fibrosis …

In the gastrointestinal tract, CFTR, in conjunction with one or several members of the SLC26
anion exchanger family, mediates electrogenic Cl− and HCO3− secretion. Na+/H+ …

Background & Aims: Bicarbonate secretion is a primary function of cholangiocytes. Either
adenosine 3′, 5′-cyclic monophosphate (cAMP) or cytosolic Ca2+ can mediate …

Fluid and HCO3− secretion are vital functions of the pancreatic duct and other secretory
epithelia. CFTR and Cl−/HCO3− exchange activity at the luminal membrane are required for …

Background & Aims Cystic fibrosis (CF) patients and CF mouse models have increased risk
for gastrointestinal tumors. CF mice show augmented intestinal proliferation of unknown …

Fluid and HCO3–secretion are vital functions of secretory epithelia. In most epithelia, this
entails HCO3–entry at the basolateral membrane, mediated by the Na+-HCO3 …