The pH of airway surface liquid (ASL) is a key factor that determines respiratory host
defense; ASL acidification impairs and alkalinization enhances key defense mechanisms …

Cystic fibrosis (CF) is the most common life-limiting recessive genetic disease among
Caucasians caused by mutations of the cystic fibrosis transmembrane conductance …

The cystic fibrosis transmembrane conductance regulator (CFTR) functions as a Cl− channel
important in transepithelial salt and water transport. While there is a paucity of direct …

Mammalian sperm acquire fertilizing ability in the female tract during a process known as
capacitation. In mouse sperm, this process is associated with increases in protein tyrosine …

A central function of epithelia is the control of the volume and electrolyte composition of
bodily fluids through vectorial transport of electrolytes and the obligatory H 2 O. In exocrine …

Genetic modification therapy is a promising therapeutic strategy for many diseases of the
lung intractable to other treatments. Lung gene therapy has been the subject of numerous …

Defective HCO3–and fluid secretion are hallmarks of the pathophysiology of the pancreas of
cystic fibrosis patients. Recently, impaired HCO3–secretion has been shown in most tissues …

The role of cystic fibrosis (CF) transmembrane conductance regulator (CFTR) in airway
epithelial wound repair was investigated using normal human bronchial epithelial (NHBE) …

The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-activated Cl−
channel that is defective in cystic fibrosis. This statement is found in most of the articles …

Acid secretion and proton conductive pathways across primary human airway surface
epithelial cultures were investigated with the pH stat method in Ussing chambers and by …