Novel anti-inflammatory approaches to COPD

M Cazzola, NA Hanania, CP Page… - International journal of …, 2023 - Taylor & Francis
Airway inflammation, driven by different types of inflammatory cells and mediators, plays a
fundamental role in COPD and its progression. Neutrophils, eosinophils, macrophages, and …

Granzyme B may act as an effector molecule to control the inflammatory process in Copd

WD Kim, DD Sin - COPD: Journal of Chronic Obstructive …, 2024 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD) is caused by smoking, but only a small
proportion of smokers have disease severe enough to develop COPD. COPD is not always …

Risk Factors of Rapid FEV1 Decline in a Real-World Chronic Obstructive Pulmonary Disease Cohort

HW Lee, JK Lee, MG Lee, KC Shin, SW Ra, TH Kim… - Respiration, 2022 - karger.com
Background: Rapid forced expiratory volume in 1 s (FEV1) decliners have been considered
a unique subgroup of patients with chronic obstructive pulmonary disease (COPD). Rapid …

Classes of drugs that target the cellular components of inflammation under clinical development for COPD

MG Matera, L Calzetta, R Annibale… - Expert Review of …, 2021 - Taylor & Francis
Introduction The persistent inflammation that characterizes COPD and affects its natural
course also impacting on symptoms has prompted research to find molecules that can …

[HTML][HTML] Phenotype of Chronic Obstructive Pulmonary Disease Based on Computed Tomography–Defined Underlying Pathology

WD Kim - Tuberculosis and Respiratory Diseases, 2022 - ncbi.nlm.nih.gov
Chronic obstructive pulmonary disease (COPD) is a complex and heterogeneous disease.
Not all patients with COPD respond to available drugs. Identifying respondents to therapy is …

[HTML][HTML] Screening of four lysosome-related genes in sepsis based on RNA sequencing technology

G Chen, W Zhang, C Wang, M Chen, Y Hu, Z Wang - BMC immunology, 2023 - Springer
Purpose Screening of lysosome-related genes in sepsis patients to provide direction for
lysosome-targeted therapy. Methods Peripheral blood samples were obtained from 22 …

[HTML][HTML] Potential marker genes for chronic obstructive pulmonary disease revealed based on single-cell sequencing and Mendelian randomization analysis

G Sun, Y Zhou, X Han, X Che, S Yu, D Song… - Aging (Albany …, 2024 - ncbi.nlm.nih.gov
Background: Progress is being made in the prevention and treatment of chronic obstructive
pulmonary disease (COPD), but it is still unsatisfactory. With the development of genetic …

[HTML][HTML] Differential decline of lung function in COPD patients according to structural abnormality in chest CT

HW Lee, JK Lee, Y Kim, AS Jang, Y il Hwang, JH Lee… - Heliyon, 2024 - cell.com
Background Different progressions or prognoses of chronic obstructive pulmonary disease
(COPD) have been reported according to structural abnormalities based on chest computed …

Risk Factors of Rapid Lung Function Decline in COPD Patients of Real World

HW Lee, JK Lee, MG Lee, KC Shin, SW Ra, TH Kim… - 2021 - researchsquare.com
Background: Rapid lung function decliners have been considered a unique subgroup of
patients with chronic obstructive pulmonary disease (COPD). A rapid decline manifests early …