Approximately 6% of adults worldwide have atherosclerosis and thrombosis of the lower
limb arteries (peripheral artery disease (PAD)) and the prevalence is rising. PAD causes leg …

Mechanical stress from haemodynamic perturbations or interventional manipulation of
epicardial coronary atherosclerotic plaques with inflammatory destabilization can release …

Ischemic heart disease is the greatest health burden and most frequent cause of death
worldwide. Myocardial ischemia/reperfusion is the pathophysiological substrate of ischemic …

Neutrophils and platelets are among the most abundant cell types in peripheral blood and
characterized by high plasticity and a readily available reservoir of surface proteins and …

Coronary atherosclerosis is a chronic pathological process that involves inflammation
together with endothelial dysfunction and lipoprotein dysregulation. Experimental studies …

Aims Rupture of the fibrous cap (RFC) and erosion of an intact fibrous cap (IFC) are the two
predominant mechanisms causing acute coronary syndromes (ACS). It is uncertain whether …

The leading cause of heart disease in developed countries is coronary atherosclerosis,
which is not simply a result of ageing but a chronic inflammatory process that can lead to …

The aggregate index of systemic inflammation (AISI), systemic inflammation response index
(SIRI), and neutrophil-to-lymphocyte* platelet ratio (NLRP) are novel indices that …

Atherosclerosis, a lipid‐driven inflammatory disease, is the main underlying cause of
cardiovascular diseases (CVDs) both in men and women. Sex‐related dimorphisms …

Hypertension is one of the most important risk factors for coronary heart disease (CHD). The
regulation of blood pressure plays a significant role in the development and prognosis of …