We show that Ydr049 (renamed VCP/Cdc48-associated mitochondrial stress-responsive—
Vms1), a member of an unstudied pan-eukaryotic protein family, translocates from the …

Background The maintenance of cell metabolism and homeostasis is a fundamental
characteristic of living organisms. In eukaryotes, mitochondria are the cornerstone of these …

Loss-of-function mutations of the parkin gene are a major cause of early-onset
parkinsonism. To explore the mechanism by which loss of parkin function results in …

The SCF (Skp1–Cullin–F-box) E3 ubiquitin ligase family was discovered through genetic
requirements for cell cycle progression in budding yeast. In these multisubunit enzymes, an …

Mitofusins and Drp1 are key components in mitochondrial membrane fusion and division,
but the molecular mechanism underlying the regulation of their activities remains to be …

In this study, we have identified a novel mito chondrial ubiquitin l igase, designated MITOL,
which is localized in the mitochondrial outer membrane. MITOL possesses a Plant Homeo …

Mitochondrial fusion in higher eukaryotes requires at least two essential GTPases, Mitofusin
1 and Mitofusin 2 (Mfn2). We have created an activated mutant of Mfn2, which shows …

Mitochondrial fusion is a highly coordinated process that mixes and unifies the mitochondrial
compartment for normal mitochondrial functions and mitochondrial DNA inheritance …

Intermediate filaments (IFs) play a key role in the integration of structure and function of
striated muscle, primarily by mediating mechanochemical links between the contractile …

Mitochondria perform multiple functions critical to the maintenance of cellular homoeostasis
and their dysfunction leads to disease. Several lines of evidence suggest the presence of a …