Advances in biomaterials for drug delivery

OS Fenton, KN Olafson, PS Pillai… - Advanced …, 2018 - Wiley Online Library
Advances in biomaterials for drug delivery are enabling significant progress in biology and
medicine. Multidisciplinary collaborations between physical scientists, engineers, biologists …

Stimuli-responsive In situ gelling system for nose-to-brain drug delivery

M Agrawal, S Saraf, S Saraf, SK Dubey, A Puri… - Journal of Controlled …, 2020 - Elsevier
The diagnosis and treatment of neurological ailments always remain an utmost challenge for
research fraternity due to the presence of BBB. The intranasal route appeared as an …

[HTML][HTML] Physicochemical properties of mucus and their impact on transmucosal drug delivery

J Leal, HDC Smyth, D Ghosh - International journal of pharmaceutics, 2017 - Elsevier
Mucus is a selective barrier to particles and molecules, preventing penetration to the
epithelial surface of mucosal tissues. Significant advances in transmucosal drug delivery …

[HTML][HTML] Recent advances in carrier mediated nose-to-brain delivery of pharmaceutics

V Bourganis, O Kammona, A Alexopoulos… - European Journal of …, 2018 - Elsevier
Central nervous system (CNS) disorders (eg, multiple sclerosis, Alzheimer's disease, etc.)
represent a growing public health issue, primarily due to the increased life expectancy and …

Basics and recent advances in peptide and protein drug delivery

BJ Bruno, GD Miller, CS Lim - Therapeutic delivery, 2013 - Taylor & Francis
While the peptide and protein therapeutic market has developed significantly in the past
decades, delivery has limited their use. Although oral delivery is preferred, most are …

An overview of clinical and commercial impact of drug delivery systems

AC Anselmo, S Mitragotri - Journal of Controlled Release, 2014 - Elsevier
Drug delivery systems are widely researched and developed to improve the delivery of
pharmaceutical compounds and molecules. The last few decades have seen a marked …

Administration of substances to laboratory animals: routes of administration and factors to consider

PV Turner, T Brabb, C Pekow… - Journal of the American …, 2011 - ingentaconnect.com
Administration of substances to laboratory animals requires careful consideration and
planning to optimize delivery of the agent to the animal while minimizing potential adverse …

Ultrasound-mediated blood–brain barrier disruption for targeted drug delivery in the central nervous system

M Aryal, CD Arvanitis, PM Alexander… - Advanced drug delivery …, 2014 - Elsevier
The physiology of the vasculature in the central nervous system (CNS), which includes the
blood–brain barrier (BBB) and other factors, complicates the delivery of most drugs to the …

Pharmacokinetics and pharmacodynamics of intranasal solid lipid nanoparticles and nanostructured lipid carriers for nose-to-brain delivery

TTL Nguyen, HJ Maeng - Pharmaceutics, 2022 - mdpi.com
Nose-to-brain drug delivery has been of great interest for the treatment of many central
nervous system (CNS) diseases and psychiatric disorders over past decades. Several …

Intranasal drug delivery: how, why and what for?

A Pires, A Fortuna, G Alves… - Journal of Pharmacy and …, 2009 - estudogeral.uc.pt
Over the recent decades the interest in intranasal delivery as a non-invasive route for drugs
is increased. Since the nasal mucosa offers numerous benefits as a target tissue for drug …