Nonribosomal peptide synthesis—principles and prospects
RD Süssmuth, A Mainz - Angewandte Chemie International …, 2017 - Wiley Online Library
Nonribosomal peptide synthetases (NRPSs) are large multienzyme machineries that
assemble numerous peptides with large structural and functional diversity. These peptides …
assemble numerous peptides with large structural and functional diversity. These peptides …
S‐Adenosyl‐Methionine‐Dependent Methyltransferases: Highly Versatile Enzymes in Biocatalysis, Biosynthesis and Other Biotechnological Applications
AW Struck, ML Thompson, LS Wong… - …, 2012 - Wiley Online Library
S‐adenosyl methionine (SAM) is a universal biological cofactor that is found in all branches
of life where it plays a critical role in the transfer of methyl groups to various biomolecules …
of life where it plays a critical role in the transfer of methyl groups to various biomolecules …
Natural products version 2.0: connecting genes to molecules
CT Walsh, MA Fischbach - Journal of the American Chemical …, 2010 - ACS Publications
Natural products have played a prominent role in the history of organic chemistry, and they
continue to be important as drugs, biological probes, and targets of study for synthetic and …
continue to be important as drugs, biological probes, and targets of study for synthetic and …
Explorations of catalytic domains in non-ribosomal peptide synthetase enzymology
GH Hur, CR Vickery, MD Burkart - Natural product reports, 2012 - pubs.rsc.org
Covering up to the end of 2011 Many pharmaceuticals on the market today belong to a large
class of natural products called nonribosomal peptides (NRPs). Originating from bacteria …
class of natural products called nonribosomal peptides (NRPs). Originating from bacteria …
Architectures, mechanisms and molecular evolution of natural product methyltransferases
DK Liscombe, GV Louie, JP Noel - Natural product reports, 2012 - pubs.rsc.org
Covering: up to January 2012 The addition of a methyl moiety to a small chemical is a
common transformation in the biosynthesis of natural products across all three domains of …
common transformation in the biosynthesis of natural products across all three domains of …
[HTML][HTML] Glycopeptide antibiotic biosynthesis
Glycopeptides such as vancomycin, teicoplanin and telavancin are essential for treating
infections caused by Gram-positive bacteria. Unfortunately, the dwindled pipeline of new …
infections caused by Gram-positive bacteria. Unfortunately, the dwindled pipeline of new …
Structural biology of nonribosomal peptide synthetases
The nonribosomal peptide synthetases are modular enzymes that catalyze synthesis of
important peptide products from a variety of standard and non-proteinogenic amino acid …
important peptide products from a variety of standard and non-proteinogenic amino acid …
[HTML][HTML] Complex peptide natural products: biosynthetic principles, challenges and opportunities for pathway engineering
SL Wenski, S Thiengmag, EJN Helfrich - Synthetic and systems …, 2022 - Elsevier
Complex peptide natural products exhibit diverse biological functions and a wide range of
physico-chemical properties. As a result, many peptides have entered the clinics for various …
physico-chemical properties. As a result, many peptides have entered the clinics for various …
Dysregulation of fatty acid synthesis and glycolysis in non-Hodgkin lymphoma
AP Bhatt, SR Jacobs, AJ Freemerman… - Proceedings of the …, 2012 - National Acad Sciences
The metabolic differences between B-NHL and primary human B cells are poorly
understood. Among human B-cell non-Hodgkin lymphomas (B-NHL), primary effusion …
understood. Among human B-cell non-Hodgkin lymphomas (B-NHL), primary effusion …
Biocatalytic Fluoroalkylation Using Fluorinated S-Adenosyl-l-methionine Cofactors
W Ding, M Zhou, H Li, M Li, Y Qiu, Y Yin, L Pan… - Organic …, 2023 - ACS Publications
Modification of organic molecules with fluorine functionalities offers a critical approach to
develop new pharmaceuticals. Here, we report a multienzyme strategy for biocatalytic …
develop new pharmaceuticals. Here, we report a multienzyme strategy for biocatalytic …