[HTML][HTML] External stimulation: A potential therapeutic strategy for tendon-bone healing

S Fu, Y Lan, G Wang, D Bao, B Qin, Q Zheng… - … in Bioengineering and …, 2023 - frontiersin.org
Injuries at the tendon-bone interface are very common in the field of sports medicine, and
healing at the tendon-bone interface is complex. Injuries to the tendon-bone interface can …

[HTML][HTML] Mechanical stimulation improves rotator cuff tendon-bone healing via activating IL-4/JAK/STAT signaling pathway mediated macrophage M2 polarization

Y Liu, L Wang, S Li, T Zhang, C Chen, J Hu… - Journal of Orthopaedic …, 2022 - Elsevier
Background It is well known that appropriate mechanical stimulation benefits tendon-bone
(TB) healing, however, the mechanisms behind this are still uncovered completely. Here, we …

The mechanism of bone healing after traumatic brain injury

Y Xiong, W Zhong, B Mi - Brain‐X, 2023 - Wiley Online Library
A growing body of evidence suggests that patients who experience traumatic brain injuries
(TBIs) exhibit significantly shorter healing periods compared to those with isolated fractures …

[HTML][HTML] Exosomes from CD133+ human urine-derived stem cells combined adhesive hydrogel facilitate rotator cuff healing by mediating bone marrow mesenchymal …

X Tong, Y Xu, T Zhang, C Deng, J Xun, D Sun… - Journal of Orthopaedic …, 2023 - Elsevier
Background The inadequate regeneration of natural tissue (mainly fibrocartilage) between
tendon and bone during rotator cuff (RC) repair results in an unsatisfactory quality of RC …

A Combined Treatment of BMP2 and Soluble VEGFR1 for the Enhancement of Tendon-Bone Healing by Regulating Injury-Activated Skeletal Stem Cell Lineage

L Wang, L Wan, T Zhang, C Guan… - … American Journal of …, 2024 - journals.sagepub.com
Background: Bone morphogenetic protein 2 (BMP2) is an appealing osteogenic and
chondrogenic growth factor for promoting tendon-bone healing. Recently, it has been …

[HTML][HTML] Comparative effect of skeletal stem cells versus bone marrow mesenchymal stem cells on rotator cuff tendon-bone healing

L Wang, C Guan, T Zhang, Y Zhou, Y Liu, J Hu… - Journal of Orthopaedic …, 2024 - Elsevier
Background Bone marrow mesenchymal stem cells (BMSCs) have immense potential in
applications for the enhancement of tendon-bone (TB) healing. Recently, it has been well …

[HTML][HTML] TGF-β1 derived from macrophages contributes to load-induced tendon-bone healing in the murine rotator cuff repair model by promoting chondrogenesis

L Wang, S Li, H Xiao, T Zhang, Y Liu, J Hu… - Bone & Joint …, 2023 - boneandjoint.org.uk
Aims It has been established that mechanical stimulation benefits tendon-bone (TB) healing,
and macrophage phenotype can be regulated by mechanical cues; moreover, the …

[HTML][HTML] Rotator cuff healing is regulated by the lymphatic vasculature

X Tong, T Zhang, S Li, Y Chen, Y Xu, C Deng… - Journal of Orthopaedic …, 2023 - Elsevier
Background Despite great advances in surgical techniques for rotator cuff tear (RCT) over
the past decades, the postoperative failure rate of RCT is still high due to the poor healing …

Single-cell RNA sequencing reveals cellular and molecular heterogeneity in fibrocartilaginous enthesis formation

T Zhang, L Wan, H Xiao, L Wang, J Hu, H Lu - Elife, 2023 - elifesciences.org
The attachment site of the rotator cuff (RC) is a classic fibrocartilaginous enthesis, which is
the junction between bone and tendon with typical characteristics of a fibrocartilage …

[HTML][HTML] Intermittent fasting promotes repair of rotator cuff injury in the early postoperative period by regulating the gut microbiota

S Xie, C Guan, T Huang, Y Liu, F Yuan, D Xu - Journal of Orthopaedic …, 2022 - Elsevier
Background The repair of rotator cuff injury is affected by lifestyle and metabolic factors.
Intermittent fasting (IF) can promote repair of damaged tissue by regulating intestinal flora …