The skeleton is a highly innervated organ in which nerve fibers interact with various skeletal
cells. Peripheral nerve endings release neurogenic factors and sense skeletal signals …

While bone tissue is known for its inherent regenerative abilities, various pathological
conditions and trauma can disrupt its meticulously regulated processes of bone formation …

Infected bone fractures remain a major clinical challenge for orthopedic surgeons. From a
tissue regeneration perspective, biomaterial scaffolds with antibacterial and osteoinductive …

Polyetheretherketone (PEEK) has been widely used as orthopedic implants, but the poor
antimicrobial and osseointegration properties hinder its advanced clinical applications. Most …

Bone resorption occurs after bone grafting, however, contemporaneous reconstruction of the
innervation of the bone graft is a potential treatment to maintain the bone mass of the graft …

Tissue engineering holds great potential for tissue repair and rejuvenation. Plant-derived
exosome-like nanoparticles (ELNs) have recently emerged as a promising avenue in tissue …

The clinical indications reveal that traumatic brain injury (TBI) accelerates the process of
limb bone regeneration. However, the mechanisms underlying this phenomenon remain …

Despite considerable advances in artificial bone tissues, the absence of neural network
reconstruction in their design often leads to delayed or ineffective bone healing. Hence, we …

Over the past decades, emerging evidence in the literature has demonstrated that the
innervation of bone is a crucial modulator for skeletal physiology and pathophysiology. The …

Postmenopausal osteoporosis is associated with bone formation inhibition mediated by the
impaired osteogenic differentiation potential of bone marrow mesenchymal stem cells …