The multifaceted nature of antimicrobial peptides: Current synthetic chemistry approaches and future directions

BH Gan, J Gaynord, SM Rowe, T Deingruber… - Chemical Society …, 2021 - pubs.rsc.org
Bacterial infections caused by 'superbugs' are increasing globally, and conventional
antibiotics are becoming less effective against these bacteria, such that we risk entering a …

The value of antimicrobial peptides in the age of resistance

M Magana, M Pushpanathan, AL Santos… - The lancet infectious …, 2020 - thelancet.com
Accelerating growth and global expansion of antimicrobial resistance has deepened the
need for discovery of novel antimicrobial agents. Antimicrobial peptides have clear …

Antimicrobial peptides, conventional antibiotics, and their synergistic utility for the treatment of drug‐resistant infections

Y Zhu, W Hao, X Wang, J Ouyang… - Medicinal Research …, 2022 - Wiley Online Library
Antimicrobial peptides (AMPs), also known as host defense peptides (HDPs), are important
effector immune defense molecules in multicellular organisms. AMPs exert their …

[HTML][HTML] Antimicrobial peptides: an emerging category of therapeutic agents

M Mahlapuu, J Håkansson, L Ringstad… - Frontiers in cellular and …, 2016 - frontiersin.org
Antimicrobial peptides (AMPs), also known as host defense peptides, are short and
generally positively charged peptides found in a wide variety of life forms from …

Mini review on antimicrobial peptides, sources, mechanism and recent applications

JK Boparai, PK Sharma - Protein and peptide letters, 2020 - ingentaconnect.com
Antimicrobial peptides in recent years have gained increased interest among scientists,
health professionals and the pharmaceutical companies owing to their therapeutic potential …

Antibiotic resistance breakers: current approaches and future directions

M Laws, A Shaaban, KM Rahman - FEMS microbiology reviews, 2019 - academic.oup.com
Infections of antibiotic-resistant pathogens pose an ever-increasing threat to mankind. The
investigation of novel approaches for tackling the antimicrobial resistance crisis must be part …

Considerations and caveats in combating ESKAPE pathogens against nosocomial infections

YX Ma, CY Wang, YY Li, J Li, QQ Wan… - Advanced …, 2020 - Wiley Online Library
ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella
pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter …

The vast structural diversity of antimicrobial peptides

J Koehbach, DJ Craik - Trends in Pharmacological Sciences, 2019 - cell.com
Antimicrobial peptides (AMPs) occur in all kingdoms of life and are integral to host defense.
They have diverse structures and target a variety of organisms, both by nonspecific …

Advances in development of antimicrobial peptidomimetics as potential drugs

N Molchanova, PR Hansen, H Franzyk - Molecules, 2017 - mdpi.com
The rapid emergence of multidrug-resistant pathogens has evolved into a global health
problem as current treatment options are failing for infections caused by pan-resistant …

Host defense peptides: Dual antimicrobial and immunomodulatory action

M Drayton, JP Deisinger, KC Ludwig… - International Journal of …, 2021 - mdpi.com
The rapid rise of multidrug-resistant (MDR) bacteria has once again caused bacterial
infections to become a global health concern. Antimicrobial peptides (AMPs), also known as …