Aggregation of the high-affinity immunoglobulin E (IgE) receptor (FcϵRI) on mast cells
induces a number of biochemical events, including protein-tyrosine phosphorylation leading …

Casitas B cell lymphoma-b (Cbl-b) is a vital negative regulator of TCR and BCR signaling
pathways, playing a significant role in setting an appropriate threshold for the activation of T …

The distinction of self from non-self is crucial to prevent autoreactivity and ensure protection
from infectious agents and tumors. Maintaining the balance between immunity and tolerance …

Germinal centers (GCs) are sites at which B cells proliferate and mutate their antibody-
encoding genes in the dark zone (DZ), followed by affinity-based selection in the light zone …

Our laboratory has found that the 154aa RING finger protein 11 (RNF11), has modular
domains and motifs including a RING-H2 finger domain, a PY motif, an ubiquitin interacting …

Cross-presentation of dead cell-associated antigens by conventional dendritic cells type 1
(cDC1s) is critical for CD8+ T cells response against many tumors and viral infections. It is …

Abstract Epstein–Barr virus (EBV), a human herpesvirus associated with lymphoid and
epithelial cell tumors, encodes several proteins that exploit the ubiquitin–proteasome system …

Background There are three major B-cell compartments in peripheral lymphoid organs: the
germinal center (GC), the mantle zone (MNZ) and the marginal zone (MGZ). Unique sets of …

Background Casitas B lymphoma-b (Cbl-b) is a central negative regulator of cytotoxic T and
natural killer (NK) cells and functions as an intracellular checkpoint in cancer. In particular …

Objective B cells play a dominant role in the pathogenesis of several autoimmune diseases,
including systemic lupus erythematosus. It is not well understood how B cell signaling …