Pathophysiological effects of contemporary lifestyle on evolutionary-conserved survival mechanisms in polycystic ovary syndrome

J Parker - Life, 2023 - mdpi.com
Polycystic ovary syndrome (PCOS) is increasingly being characterized as an evolutionary
mismatch disorder that presents with a complex mixture of metabolic and endocrine …

Unraveling the complexity of the molecular pathways associated with polycystic ovary syndrome (PCOS) and identifying molecular targets for therapeutic development …

AB Sikiru, MA Adeniran, K Akinola, H Behera… - Middle East Fertility …, 2023 - Springer
Background Polycystic ovary syndrome (PCOS) is the most typical endocrine disorder
affecting women worldwide. Although the etiology of PCOS is not fully understood, genetic …

Bisphenol A and its structural analogues exhibit differential potential to induce mitochondrial dysfunction and apoptosis in human granulosa cells

G Xu, M Huang, J Hu, S Liu, M Yang - Food and Chemical Toxicology, 2024 - Elsevier
Bisphenol A (BPA) is an endocrine disruptor strongly associated with ovarian dysfunction.
BPA is being substituted by structurally similar chemicals, such as bisphenol S (BPS) …

[HTML][HTML] High dietary copper intake induces perturbations in the gut microbiota and affects host ovarian follicle development

Q Wang, Y Sun, A Zhao, X Cai, A Yu, Q Xu… - Ecotoxicology and …, 2023 - Elsevier
Increasing evidence has shown that gut microbes play an important role in the reproductive
endocrine system and the development of polycystic ovary syndrome (PCOS). However …

[HTML][HTML] Molecular mechanisms of cadmium-induced cytotoxicity in human ovarian granulosa cells identified using integrated omics

Z Lv, J Hu, M Huang, G Pan, G Xu, M Yang - … and Environmental Safety, 2024 - Elsevier
Epidemiological and clinical data have demonstrated that exposure to cadmium (Cd), a toxic
heavy metal, is associated with an increased risk of female infertility. Granulosa cells, the …

Regulation of Insulin Resistance, Lipid Profile and Glucose Metabolism Associated with Polycystic Ovary Syndrome by Tinospora cordifolia

R Rani, HR Chitme, N Kukreti, P Pant… - Nutrients, 2023 - mdpi.com
Background: The plant Tinospora cordifolia (TC), traditionally known as guduchi or giloy, is
used for a number of health conditions as a nutritional supplement and rejuvenation …

Perfluorooctane sulfonic acid modulates expression of placental steroidogenesis-associated genes and hormone levels in pregnant rats

SV Dangudubiyyam, JS Mishra, S Kumar - Reproductive Toxicology, 2023 - Elsevier
Perfluorooctane sulfonate (PFOS) is a widespread and persistent chemical in the
environment. Reports show that PFOS is a potential endocrine disruptor; however, the …

Endocrine-disrupting chemicals and hormonal profiles in PCOS women: A comparative study between urban and rural environment

J Patel, H Chaudhary, S Panchal, T Joshi… - Reproductive Toxicology, 2024 - Elsevier
Abstract Polycystic Ovary Syndrome (PCOS), a multifaceted endocrine disorder, affects a
significant proportion of women globally, with its etiology rooted in both genetic and …

Mechanism of elevated LH/FSH ratio in lean PCOS revisited: a path analysis

G Pratama, B Wiweko, Asmarinah, IS Widyahening… - Scientific reports, 2024 - nature.com
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting 5–20%
of reproductive-age women. However, the treatment of PCOS is mainly based on symptoms …

ApoC3 is expressed in oocytes and increased expression is associated with PCOS progression

J Zhou, H Mo, Q Feng, L Li, J La - Journal of Ovarian Research, 2023 - Springer
Background Polycystic ovary syndrome (PCOS) is a lifelong metabolic disorder and the most
common cause of anovulatory infertility affecting women in reproductive age. Our recent …