The final step of biomineralization is a chemical precipitation reaction that occurs
spontaneously in supersaturated or metastable salt solutions. Genetic programs direct …

Sixty-six years have elapsed since the discovery of fetuin in 1944, but its importance in
mammalian physiology has only recently been appreciated. Fetuin, first isolated from fetal …

Genetic evidence from mutant mice suggests that α 2-HS glycoprotein/fetuin-A (Ahsg) is a
systemic inhibitor of precipitation of basic calcium phosphate preventing unwanted …

Fetuins are serum proteins with diverse functions including the regulation of osteogenesis
and inhibition of unwanted mineralization. Besides the α2-Heremans and Schmid …

Vascular calcification predicts an increased risk for cardiovascular events/mortality in
atherosclerosis, diabetes, and ESRD. Serum concentrations of α 2-Heremens-Schmid …

We present data suggesting a function of α 2-HS glycoproteins/fetuins in serum and in
mineralization, namely interference with calcium salt precipitation. Fetuins occur in high …

We proposed that the α 2-Heremans Schmid glycoprotein/fetuin family of serum proteins
inhibits unwanted mineralization. To test this hypothesis in animals, we cloned the mouse …

Human fetuin,(α2-Heremans Schmid Glycoprotein (α2-HSG)], is a natural inhibitor of insulin
receptor tyrosine kinase activity (IR-TKA). Previously, we have demonstrated that α2-HSG …

A set of orthologous plasma proteins found in human, sheep, pig, cow and rodents, now
collectively designated fetuin-A, constitutes the fetuin family. Fetuin-A has been identified as …

Psoriasis is a chronic inflammatory skin disease most common in Europe, North America,
and Australia. The etiology and pathomechanisms underlying the evolution and persistence …