Defining dry eye from a clinical perspective

K Tsubota, SC Pflugfelder, Z Liu, C Baudouin… - International journal of …, 2020 - mdpi.com
Over the past decades, the number of patients with dry eye disease (DED) has increased
dramatically. The incidence of DED is higher in Asia than in Europe and North America …

TFOS DEWS II management and therapy report

L Jones, LE Downie, D Korb, JM Benitez-del-Castillo… - The ocular …, 2017 - Elsevier
The members of the Management and Therapy Subcommittee undertook an evidence-
based review of current dry eye therapies and management options. Management options …

TFOS DEWS II pain and sensation report

C Belmonte, JJ Nichols, SM Cox, JA Brock, CG Begley… - The ocular …, 2017 - Elsevier
Pain associated with mechanical, chemical, and thermal heat stimulation of the ocular
surface is mediated by trigeminal ganglion neurons, while cold thermoreceptors detect …

Dry eye

JA Clayton - New England Journal of Medicine, 2018 - Mass Medical Soc
Dry Eye Dry eye is a common, painful ocular disturbance that can result from systemic
inflammatory diseases, localized eye problems, or commonly used medications. Current …

TFOS DEWS II sex, gender, and hormones report

DA Sullivan, EM Rocha, P Aragona, JA Clayton, J Ding… - The ocular …, 2017 - Elsevier
One of the most compelling features of dry eye disease (DED) is that it occurs more
frequently in women than men. In fact, the female sex is a significant risk factor for the …

In vivo confocal microscopy of corneal nerves in health and disease

A Cruzat, Y Qazi, P Hamrah - The ocular surface, 2017 - Elsevier
In vivo confocal microscopy (IVCM) is becoming an indispensable tool for studying corneal
physiology and disease. Enabling the dissection of corneal architecture at a cellular level …

Role of corneal nerves in ocular surface homeostasis and disease

M Labetoulle, C Baudouin, M Calonge… - Acta …, 2019 - Wiley Online Library
Corneal nerves are key components of the physiological system that controls ocular surface
homeostasis. The cornea is primarily innervated by the ophthalmic branch of the trigeminal …

Prevalence and risk factors of dry eye in 79,866 participants of the population-based Lifelines cohort study in the Netherlands

J Vehof, H Snieder, N Jansonius, CJ Hammond - The Ocular Surface, 2021 - Elsevier
Purpose To investigate the prevalence of dry eye among all adult age categories and to
discover independent risk factors by investigating a wide range of etiological categories …

TFOS Lifestyle: Impact of lifestyle challenges on the ocular surface

A Galor, AC Britten-Jones, Y Feng, G Ferrari… - The ocular …, 2023 - Elsevier
Many factors in the domains of mental, physical, and social health have been associated
with various ocular surface diseases, with most of the focus centered on aspects of dry eye …

TFOS Lifestyle: Impact of elective medications and procedures on the ocular surface

JAP Gomes, DT Azar, C Baudouin, E Bitton, W Chen… - The Ocular Surface, 2023 - Elsevier
The word “elective” refers to medications and procedures undertaken by choice or with a
lower grade of prioritization. Patients usually use elective medications or undergo elective …