Nitric oxide (NO), an endogenous, free radical, highly unstable, diatomic gaseous molecule,
plays crucial roles in several physiological and pathological processes. It has attracted …

Dimethyl fumarate (DMF) is an immunomodulatory drug currently approved for the treatment
of multiple sclerosis and psoriasis. Its benefits on ischemic stroke outcomes have recently …

Background Resveratrol is a natural phenolic compound widely found in plants. Previous
studies have suggested its neuroprotective role in cerebral ischemia due to its anti-oxidative …

Stroke is the second leading cause of death and the third leading cause of disability
worldwide. Globally, 68% of all strokes are ischemic, with 32% being hemorrhagic. Ischemic …

Nicorandil is a dual mechanism anti-anginal agent that acts as a nitric oxide (NO) donor and
a potassium (K+) channel opener. Recent studies have evaluated the effect of nicorandil on …

Background: Zinc oxide nanoparticles have been utilized in different fields over the last
decades. These nanoparticles can pose significant risks to various organs such as the liver …

Background The effect of combined nicorandil and beta-adrenergic receptor blockers (BBs)
compared with that of BBs alone on long-term clinical outcomes in patients with coronary …

Objective: Residual cardiovascular risk in patients with coronary heart disease (CHD) still
needs to be addressed in real-world practice. This study aimed to examine the clinical …

Objective: This study was aimed at investigating whether the addition of nicorandil to a
dihydropyridine calcium channel blocker (DHP-CCB) regimen might decrease the …

Excitotoxicity, caused by the excessive release of glutamate, leads to the activation of the
apoptotic process, making it a crucial factor in age-related neurodegenerative diseases. The …