Common side effects of opioid administration include sedation, dizziness, nausea, vomiting,
constipation, physical dependence, tolerance, and respiratory depression. Physical …

Objective To formulate timely evidence-based guidelines for the management of opioid-
induced bowel dysfunction. Setting Constipation is a major untoward effect of opioids …

Abstract Background The NaV1. 8 voltage-gated sodium channel, expressed in peripheral
nociceptive neurons, plays a role in transmitting nociceptive signals. The effect of VX-548 …

Patients with cancer have diverse symptoms, impairments in physical and psychological
functioning, and other difficulties that can undermine their quality of life. If inadequately …

Opium is arguably one of the oldest herbal medicines, being used as analgesic, sedative
and antidiarrheal drug for thousands of years. These effects mirror the actions of the …

BACKGROUND: Postoperative pain management remains a significant challenge after
abdominal surgery. OBJECTIVE: The aim of this meta-analysis was to evaluate the efficacy …

Background Intravenous infusion of lidocaine decreases postoperative pain and speeds the
return of bowel function. The authors therefore tested the hypothesis that perioperative …

There has been an alarming increase in the prescription of opiates and opioids for chronic
non-cancer pain in the past 15 years. It is estimated that opiate-induced constipation (OIC) is …

Opioids are the most commonly prescribed medications to treat severe pain in the Western
world. It has been estimated that up to 90% of American patients presenting to specialized …

As a result of the undesired action of opioids on the gastrointestinal (GI) tract, patients
receiving opioid medication for chronic pain often experience opioid‐induced bowel …