Near-Infrared Fluorescent Probe Activated by Nitroreductase for In Vitro and In Vivo Hypoxic Tumor Detection

S Karan, MY Cho, H Lee, H Lee, HS Park… - Journal of Medicinal …, 2021 - ACS Publications
Tumor hypoxia is correlated with increased resistance to chemotherapy and poor overall
prognoses across a number of cancer types. We present here a cancer cell-selective and …

[HTML][HTML] Soy lecithin-derived liposomal delivery systems: Surface modification and current applications

NTT Le, VD Cao, TNQ Nguyen, TTH Le… - International journal of …, 2019 - mdpi.com
The development of natural phospholipids for nanostructured drug delivery systems has
attracted much attention in the past decades. Lecithin that was derived from naturally …

Antibody–drug conjugates and small molecule–drug conjugates: opportunities and challenges for the development of selective anticancer cytotoxic agents …

G Casi, D Neri - Journal of medicinal chemistry, 2015 - ACS Publications
Conventional cancer chemotherapy heavily relies on the use of cytotoxic agents, which
typically do not preferentially localize at the tumor site and cause toxicity to normal organs …

Synthesis, characterization, and in vivo targeted imaging of amine-functionalized rare-earth up-converting nanophosphors

LQ Xiong, ZG Chen, MX Yu, FY Li, C Liu, CH Huang - Biomaterials, 2009 - Elsevier
Rare-earth up-converting nanophosphors (UCNPs) have great potential to become a new
generation of biological luminescent labels, but their use has been limited by difficulties in …

[HTML][HTML] Inflammatory biomarkers in osteoarthritis

HN Daghestani, VB Kraus - Osteoarthritis and cartilage, 2015 - Elsevier
Osteoarthritis (OA) is highly prevalent and a leading cause of disability worldwide. Despite
the global burden of OA, diagnostic tests and treatments for the molecular or early …

[HTML][HTML] Targeted nanomaterials for phototherapy

U Chitgupi, Y Qin, JF Lovell - Nanotheranostics, 2017 - ncbi.nlm.nih.gov
Phototherapies involve the irradiation of target tissues with light. To further enhance
selectivity and potency, numerous molecularly targeted photosensitizers and photoactive …

[HTML][HTML] Doxorubicin-Loaded Core–Shell UiO-66@SiO2 Metal–Organic Frameworks for Targeted Cellular Uptake and Cancer Treatment

DB Trushina, AY Sapach, OA Burachevskaia… - Pharmaceutics, 2022 - mdpi.com
Beneficial features of biocompatible high-capacity UiO-66 nanoparticles, mesoporous SiO2,
and folate-conjugated pluronic F127 were combined to prepare the core–shell UiO-66 …

Core-shell structured nanoparticles for photodynamic therapy-based cancer treatment and related imaging

Y Yang, Z Zeng, E Almatrafi, D Huang, C Zhang… - Coordination Chemistry …, 2022 - Elsevier
Photodynamic therapy (PDT) is an emerging noninvasive therapy modality for treating
cancer diseases. However, conventional PDT suffers from poor stability of organic …

An implantable active-targeting micelle-in-nanofiber device for efficient and safe cancer therapy

G Yang, J Wang, Y Wang, L Li, X Guo, S Zhou - ACS nano, 2015 - ACS Publications
Nanocarriers have attracted broad attention in cancer therapy because of their ability to
carry drugs preferentially into cancer tissue, but their application is still limited due to the …

[HTML][HTML] Single-versus dual-targeted nanoparticles with folic acid and biotin for anticancer drug delivery

M Jurczyk, K Jelonek, M Musiał-Kulik, A Beberok… - Pharmaceutics, 2021 - mdpi.com
Cancer is one of the major causes of death worldwide and its treatment remains very
challenging. The effectiveness of cancer therapy significantly depends upon tumour-specific …