Spatiotemporal regulation of the activity of a vast array of intracellular proteins and signaling
pathways by reactive oxygen species (ROS) governs normal cardiovascular function …

Markers of increased oxidative stress are known to be elevated following acute myocardial
infarction and in the context of chronic left ventricular hypertrophy or heart failure, and their …

Uric acid (UA) is the end product of purine metabolism and can reportedly act as an
antioxidant. However, recently, numerous clinical and basic research approaches have …

Uric acid (urate), an organic compound comprised of carbon, nitrogen, oxygen and
hydrogen, is the final oxidation product of purine catabolism in humans, higher primates and …

Oxidative stress plays an important role in the progression of vascular endothelial
dysfunction. The two major systems generating vascular oxidative stress are the NADPH …

Background Hyperuricemia is associated with reduced survival among patients with heart
failure (HF), but the effect of gout on HF outcomes is unknown. A recent randomized trial …

In the current issue of Circulation, Anker and colleagues1 report that elevated levels of uric
acid (UA) predict mortality and the need for heart transplantation in patients with congestive …

Oxidative stress (OS) is mediated by reactive oxygen species (ROS), which in
cardiovascular and other disease states, damage DNA, lipids, proteins, other cellular and …

Endothelial dysfunction crucially contributes to the development of impaired coronary and
systemic perfusion as well as reduced exercise capacity in patients with congestive heart …

Although interactions between superoxide () and nitric oxide underlie many physiologic and
pathophysiologic processes, regulation of this crosstalk at the enzymatic level is poorly …