Background—In idiopathic pulmonary arterial hypertension (IPAH), increased right
ventricular (RV) power is required to maintain cardiac output. For this, RV O2 consumption …

Heart failure is a complex syndrome of numerous dysfunctional components which converge
to cause chronic progressive failure of ventricular contractile function and maintenance of …

Purine nucleotide liberation and their metabolic rate of interconversion may be important in
the development of hypertension and its renal consequences. In the present study, blood …

Basic research and clinical studies have implicated a role for hyperuricemia and for xanthine
oxidoreductase (XOR), the enzyme that generates uric acid (UA), in not only gout but also …

Adaptation of the heart to intrinsic and external stress involves complex modifications at the
molecular and cellular levels that lead to tissue remodeling, functional and metabolic …

There is a need for a cost-effective prognostic biomarker in heart failure (HF). Substantial
evidence suggests that uric acid (UA) is an independent marker for adverse prognosis in …

Oxypurinol, an inhibitor of xanthine oxidase (XO), is being studied to block XO-catalyzed
superoxide radical formation and thereby treat and protect failing heart tissue. Allopurinol, a …

Hyperuricemia increases the risk of heart failure, and higher levels of serum uric acid are
seen in patients who have worse ventricular function, functional capacity, and prognosis …

It has been reported that the xanthine oxidase inhibitor, allopurinol, has a protective effect on
ischemia–reperfusion injury, but the precise mechanism of its action is still unclear …

Nitric oxide (NO) is a highly reactive, free radical signalling molecule that is constitutively
released in cardiomyocytes by both the endothelial and neuronal isoforms of nitric oxide …