Reevaluation of treatment guidelines for Old and New World leishmaniasis is urgently
needed on a global basis because treatment failure is an increasing problem. Drug …

Progress in the diagnosis of leishmaniases depends on the development of effective
methods and the discovery of suitable biomarkers. We propose firstly an update …

Aneuploidy, a genomic alternation characterized by deviations in the copy number of
chromosomes, affects organisms from early development through to aging. Although it is a …

Aneuploidy, chromosome stoichiometry that deviates from exact multiples of the haploid
compliment of an organism, exists in eukaryotic microbes, several normal human tissues …

Background Protists of the family Trypanosomatidae (phylum Euglenozoa) have gained
notoriety as parasites affecting humans, domestic animals, and agricultural plants. However …

Leishmania has a plastic genome, and drug pressure can select for gene copy number
variation (CNV). CNVs can apply either to whole chromosomes, leading to aneuploidy, or to …

Chagas disease caused by the parasite Trypanosoma cruzi affects millions of people.
Although its first genome dates from 2005, its complexity hindered a complete assembly and …

Although asexual reproduction via clonal propagation has been proposed as the principal
reproductive mechanism across parasitic protozoa of the Leishmania genus, sexual …

Aneuploidy is known to be deleterious and underlies several common human diseases,
including cancer and genetic disorders such as trisomy 21 in Down's syndrome. In contrast …

Aneuploid genomes, characterized by unbalanced chromosome stoichiometry (karyotype),
are associated with cancer malignancy and drug resistance of pathogenic fungi. The …