ABSTRACT Interleukin-2 (IL-2) is one of the key cytokines with pleiotropic effects on immune
system. It has been approved for the treatment of metastatic renal cell carcinoma and …

Background The prognosis of people with metastatic cutaneous melanoma, a skin cancer, is
generally poor. Recently, new classes of drugs (eg immune checkpoint inhibitors and small …

Accumulating evidence indicates that the innate and adaptive immune systems make a
crucial contribution to the antitumour effects of conventional chemotherapy-based and …

The incidence of melanoma is increasing worldwide, and the prognosis for patients with
high‐risk or advanced metastatic melanoma remains poor despite advances in the field …

The 10-year survival rate for patients with metastatic melanoma is less than 10%. Although
surgery and radiation therapy have a role in the treatment of metastatic disease, systemic …

Introduction Melanoma is the most serious form of skin cancer causing most of the skin
cancer-related deaths. The incidence of melanoma has risen so dramatically over past few …

Prior to the recent therapeutic advances, chemotherapy was the mainstay of treatment
options for advanced-stage melanoma. A number of studies have investigated various …

Malignant melanoma remains one of the fastest growing cancers worldwide. Although the
primary cutaneous melanoma can be managed by surgery, the advanced metastatic …

A dynamic interplay exists between host and tumor, and the ability of the tumor to evade
immune recognition often determines the clinical course of the disease. Significant …

Primary mucosal melanomas (PMMs) of the head and neck are uncommon malignancies
that arise mainly in the nasal cavity and paranasal sinuses, followed by the oral cavity. The …