Role of cholinergic signaling in Alzheimer's disease

ZR Chen, JB Huang, SL Yang, FF Hong - Molecules, 2022 - mdpi.com
Acetylcholine, a neurotransmitter secreted by cholinergic neurons, is involved in signal
transduction related to memory and learning ability. Alzheimer's disease (AD), a progressive …

Alzheimer's disease pharmacotherapy in relation to cholinergic system involvement

GD Stanciu, A Luca, RN Rusu, V Bild… - Biomolecules, 2019 - mdpi.com
Alzheimer's disease, a major and increasing global health challenge, is an irreversible,
progressive form of dementia, associated with an ongoing decline of brain functioning. The …

Potential and limits of cannabinoids in Alzheimer's disease therapy

G Abate, D Uberti, S Tambaro - Biology, 2021 - mdpi.com
Simple Summary This review was aimed at exploring the potentiality of drugging the
endocannabinoid system as a therapeutic option for Alzheimer's disease (AD). Recent …

Recent advances in the potential of cannabinoids for neuroprotection in Alzheimer's, Parkinson's, and Huntington's diseases

C Pérez-Olives, R Rivas-Santisteban, J Lillo… - Cannabinoids and …, 2020 - Springer
Three prevalent neurodegenerative diseases, Parkinson's, Alzheimer's, and Huntington's
are in need of symptomatic relief of slowing disease progression or both. This chapter …

Age and gender differences for the behavioral phenotypes of 3xTg Alzheimer's disease mice

T Pairojana, S Phasuk, P Suresh, SP Huang… - Brain Research, 2021 - Elsevier
The triple transgenic Alzheimer's disease (3xTg-AD) strain is a common mouse model used
for studying the pathology and mechanism of Alzheimer's disease (AD). The 3xTg-AD strain …

Crosstalk between the M1 muscarinic acetylcholine receptor and the endocannabinoid system: A relevance for Alzheimer's disease?

KJ Thompson, AB Tobin - Cellular Signalling, 2020 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder which accounts for 60–70% of the
50 million worldwide cases of dementia and is characterised by cognitive impairments …

Cannabinoid signaling modulation through JZL184 restores key phenotypes of a mouse model for Williams–Beuren syndrome

A Navarro-Romero, L Galera-López, P Ortiz-Romero… - Elife, 2022 - elifesciences.org
Williams–Beuren syndrome (WBS) is a rare genetic multisystemic disorder characterized by
mild-to-moderate intellectual disability and hypersocial phenotype, while the most …

Modulation of neurolipid signaling and specific lipid species in the triple transgenic mouse model of Alzheimer's disease

E González de San Román, A Llorente-Ovejero… - International journal of …, 2021 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most
common cause of dementia in aging populations. Recently, the regulation of neurolipid …

Cannabinoid receptors and glial response following a basal forebrain cholinergic lesion

A Llorente-Ovejero, I Bengoetxea de Tena… - ACS Pharmacology & …, 2022 - ACS Publications
The endocannabinoid system modulates learning, memory, and neuroinflammatory
processes, playing a key role in neurodegeneration, including Alzheimer's disease (AD) …

On the biomedical properties of endocannabinoid degradation and reuptake inhibitors: pre-clinical and clinical evidence

KJ Paredes-Ruiz, K Chavira-Ramos… - Neurotoxicity …, 2021 - Springer
The endocannabinoid system (ECS) is composed of endogenous cannabinoids;
components involved in their synthesis, transport, and degradation; and an expansive …