Sensorineural hearing loss (SNHL) can either be genetically inherited or acquired as a
result of aging, noise exposure, or ototoxic drugs. Although the precise pathophysiological …

Abstract Solute carrier family 26 (SLC26) is a family of functionally diverse anion
transporters found in all kingdoms of life. Anions transported by SLC26 proteins include …

Members of the SLC26 family constitute a conserved class of anion transport proteins, which
encompasses uncoupled transporters with channel-like properties, coupled exchangers and …

Charged moieties in the outer hair cell (OHC) membrane motor protein, prestin, are driven
by transmembrane voltage to power OHC electromotility (eM) and cochlear amplification …

Prestin (SLC26A5)-mediated voltage-driven elongations and contractions of sensory outer
hair cells within the organ of Corti are essential for mammalian cochlear amplification …

Pendrin and prestin are evolutionary-conserved membrane proteins that are essential for
normal hearing. Dysfunction of these proteins results in hearing loss in humans, and …

Abstract Pendrin (SLC26A4) is an anion exchanger expressed in the apical membranes of
selected epithelia. Pendrin ablation causes Pendred syndrome, a genetic disorder …

Vitamin C plays important roles as a cofactor in many enzymatic reactions and as an
antioxidant against oxidative stress. As some mammals including humans cannot synthesize …

SLC26A2 is a vital solute carrier responsible for transporting essential nutritional ions,
including sulfate, within the human body. Pathogenic mutations within SLC26A2 give rise to …

Mammalian SLC26 proteins are membrane-based anion transporters that belong to the
large SLC26/SulP family, and many of their variants are associated with hereditary diseases …