Glioblastoma (GBM) is the most common primary malignant intracranial tumor. Due to its
high morbidity, high mortality, high recurrence rate, and low cure rate, it has brought great …

Matrine is a quinolizidine alkaloid isolated from the roots of Sophora flavescens (Kushen),
Sophora tonkinensis, and Sophora alopecuroides (Kudouzi). Matrine and its derivatives …

Abstract Background The genus Sophora (Fabaceae) represents one of the important
medicinal plant genera regarding its chemical constituents and outstanding …

Cancer is the second leading cause of mortality and has resulted in about 9.6 million deaths
around the world in 2018. Cancer-caused deaths are expected to be 11.5 million by 2030 all …

Background Juglone is a natural pigment, which has cytotoxic effect against various human
tumor cells. However, its cytotoxicity to glioma cells, especially to tumor stem-like cells …

Background: Acute lymphoblastic leukemia (ALL) is one of the most common malignancies
among children, characterized by mass production of leukemic blasts. Chemotherapy is the …

Taking sophoridine as a lead compound, 58 sophoridine derivatives were designed,
synthesized and evaluated for their antiproliferative activity in the HepG2 cancer cell line …

New N-substituted sophoridinic acid/ester and sophoridinol derivatives were synthesized
and evaluated for their cytotoxic activity in human HepG2 hepatoma cells from the lead …

Oxymatrine (OMT), an alkaloid derived from the traditional Chinese medicine herb Sophora
flavescens Aiton, has been shown to exhibit anticancer properties on various types of cancer …

In this study, we investigated the anti-inflammatory effects of triterpenes and steroid
derivative isolated from the stem bark of Hiptage benghalensis in LPS-stimulated RAW …