Reactive oxygen species (ROS), either derived from exogenous sources or overproduced
endogenously, can disrupt the body's antioxidant defenses leading to compromised redox …

Platelets are central players in thrombosis and hemostasis but are increasingly recognized
as key components of the immune system. They shape ensuing immune responses by …

Selective serotonin reuptake inhibitors (SSRIs) have anti‐inflammatory properties that may
have clinical utility in treating severe pulmonary manifestations of COVID‐19. SSRIs exert …

Acute respiratory distress syndrome (ARDS) is a common and devastating syndrome that
contributes to serious morbidities and mortality in critically ill patients. No known …

Background There is no pharmacologic treatment for ARDS. Platelets play an important role
in the pathophysiology of ARDS. Preclinical, observational, and clinically relevant models of …

Background Acute respiratory distress syndrome (ARDS) is a life-threatening condition with
high mortality that imposes a serious medical burden. Antiplatelet therapy is a potential …

Abstract Background and Objectives Ticagrelor is an antiplatelet agent for patients with
acute coronary syndrome or a history of myocardial infarction. Two studies compared …

Hemostatic derangement is a hallmark in severe COVID-19. Markedly elevation of D-dimer
and fibrinogen degradation product levels were observed in patients with severe COVID-19 …

Background Recent studies have shown that prior antiplatelet drug use could ameliorate the
risk and mortality of acute respiratory distress syndrome (ARDS). However, the connection …

Community-acquired pneumonia (CAP) is the most common infectious disease related
cause of death worldwide despite the use of effective antimicrobials. Much of the morbidity …