Calpains are a family of proteases that were scientifically recognized earlier than
proteasomes and caspases, but remain enigmatic. However, they are known to participate in …

This article provides a comprehensive overview of the pathology of multiple sclerosis (MS),
including recent insights into its molecular neuropathology and immunology. It shows that all …

Multiple sclerosis (MS) is the most common demyelinating and an autoimmune disease of
the central nervous system characterized by immune-mediated myelin and axonal damage …

The identification of a drug that stimulates endogenous myelination and spares axon
degeneration during multiple sclerosis (MS) could potentially reduce the rate of disease …

Several drug screening campaigns identified Calpeptin as a drug candidate against SARS-
CoV-2. Initially reported to target the viral main protease (Mpro), its moderate activity in Mpro …

Spectrin cytoskeletons are found in all metazoan cells, and their physical interactions
between actin and ankyrins establish a meshwork that provides cellular structural integrity …

Neurodegeneration, along with inflammatory demyelination, is an important component of
multiple sclerosis (MS) pathogenesis. Autophagy is known to play a pivotal role in neuronal …

Background Studies have shown that transplantation of bone marrow-derived mesenchymal
stem cells (BMSCs) protects against brain damage. However, the low survival number of …

Optic neuritis (ON), which is an acute inflammatory autoimmune demyelinating disease of
the central nervous system (CNS), often occurs in multiple sclerosis (MS). ON is an early …

Background Chronic microglia-mediated inflammation and oxidative stress are well-
characterized underlying factors in neurodegenerative disease, whereby reactive …