The transport of RNA molecules from the nucleus to the cytoplasm is fundamental for gene
expression. The different RNA species that are produced in the nucleus are exported …

Alkylation lesions in DNA and RNA result from endogenous compounds, environmental
agents and alkylating drugs. Simple methylating agents, eg methylnitrosourea, tobacco …

▪ Abstract Eukaryotic mRNAs are primarily degraded by removal of the 3′ poly (A) tail,
followed either by cleavage of the 5′ cap structure (decapping) and 5′-> 3 …

Poly (A) tails are found at the 3′ ends of almost all eukaryotic mRNAs. They are bound by
two different poly (A) binding proteins, PABPC in the cytoplasm and PABPN1 in the nucleus …

Gene expression is a coordinated multistep process that begins with transcription and RNA
processing in the nucleus followed by mRNA export to the cytoplasm for translation. Here we …

A repressor of the transition to flowering in Arabidopsis is the MADS box protein
FLOWERING LOCUS C (FLC). FCA, an RNA-binding protein, and FY, a homolog of the …

The molecular mechanism underlying the retention of intron-containing mRNAs in the
nucleus is not understood. Here, we show that retention of intron-containing mRNAs in yeast …

The exosome complex is involved in multiple RNA processing and degradation pathways.
How exosome is recruited to particular RNA substrates and then chooses between RNA …

The TREX complex, which functions in mRNA export, is recruited to mRNA during splicing.
Both the splicing machinery and the TREX complex are concentrated in 20–50 discrete foci …

Over the past few decades, we have learned that eukaryotes have evolved sophisticated
means to coordinate the nuclear export of mRNAs with different steps of gene expression …