Alzheimer's disease (AD) is one of the most common neurodegenerative disorders, which is
characterized by the primary risk factor, age. Several attempts have been made to treat AD …

Simple Summary Tumor-associated macrophages (TAMs) play major roles in solid tumor
development. They can have both anti-tumor and pro-tumor properties depending on their …

Trichostatin A (TSA), a natural derivative of dienohydroxamic acid derived from a fungal
metabolite, exhibits various biological activities. It exerts antidiabetic activity and reverses …

Microtubule targeting agents (MTAs) have attracted extensive attention for cancer treatment.
However, their clinical efficacies are limited by intolerable toxicities, inadequate efficacy and …

In both developing and industrialized Countries, the growing prevalence of Type 2 Diabetes
Mellitus (T2DM) and the severity of its related complications make T2DM one of the most …

Background and purpose: Obesity is becoming a major global health issue and is mainly
induced by the accumulation of adipose tissues mediated by adipogenesis, which is …

After chemotherapy for the treatment of metastatic bladder urothelial carcinoma (UC), most
patients inevitably encounter drug resistance and resultant treatment failure …

Cullin-RING E3 ligases are involved in the ubiquitination of substrates that regulate
important biological processes and are a potential therapeutic target in many types of …

Since their discovery over two decades ago, the molecular and cellular functions of the
NIPSNAP family of proteins (NIPSNAPs) have remained elusive until recently. NIPSNAPs …

Cisplatin-based chemotherapy is the primary treatment for metastatic bladder urothelial
carcinoma (UC). Most patients inevitably encounter drug resistance and resultant disease …