Clinical studies suggest that obesity and Type 2 (insulin-resistant) diabetes impair the
structural integrity of medial temporal lobe regions involved in memory and confer greater …

Evolutionary considerations relating to efficiency in reproduction, and survival in hostile
environments, suggest that body energy stores are sensed and actively regulated, with …

There is evidence for the idea that there is biological (active) control of body weight at a
given set point. Body weight is the product of genetic effects (DNA), epigenetic effects …

This article is part of a Special Issue “Energy Balance”. Obesity and its associated
comorbidities remain at epidemic levels globally and show no signs of abatement in either …

Mounting an immune response requires substantial energy, and it is well known that marked
reductions in energy availability (eg starvation) can suppress immune function, thus …

White adipocyte proliferation is a hallmark of obesity, but it largely remains a mechanistic
mystery. We and others previously demonstrated that surgical denervation of white adipose …

Increased visceral adiposity is a risk factor for metabolic disorders such as dyslipidemia,
hypertension, insulin resistance and type 2 diabetes, whereas peripheral (subcutaneous) …

Functional and histological evidence for the sympathetic nervous system (SNS) innervation
of white adipose tissue (WAT) exists for several species; however, its sensory innervation …

Abdominal obesity is associated with metabolic risk factors for coronary heart disease
(CHD). Although we previously found that using liposuction surgery to remove abdominal …

We recently found that adipose afferent reflex (AAR) induced by chemical stimulation of
white adipose tissue (WAT) increased sympathetic outflow and blood pressure in normal …