Targeted drug delivery to tumor sites is one of the ultimate goals in drug delivery. Recent
progress in nanoparticle engineering has certainly improved drug targeting, but the results …

Discovery of insulin in the early 1900s initiated the research and development to improve
the means of therapeutic protein delivery in patients. In the past decade, great emphasis has …

In order to cure and treat health-related disorders, therapeutic substance must reach its
target site with a constant concentration over a long period of time. As oral administration is …

Abstract Cancer-associated fibroblasts (CAFs), are the key effector cells in pancreatic ductal
adenocarcinoma (PDAC), known to induce tumor growth and progression. Pancreatic …

Polymeric nanoparticles are designed to transport and deliver nitric oxide (NO) into hepatic
stellate cells (HSCs) for the potential treatment of both liver fibrosis and portal hypertension …

Renal fibrosis leads to end-stage renal disease demanding renal replacement therapy
because no adequate treatment exists. IFN-γ is an antifibrotic cytokine that may attenuate …

Pancreatic stellate cells (PSCs) are the key precursor cells for cancer-associated fibroblasts
(CAFs) in pancreatic tumor stroma. In this study, we explored miRNA as therapeutic targets …

Pancreatic stellate cells (PSCs) are the precursors of cancer-associated fibroblasts (CAFs),
which potentiate pancreatic tumor growth and progression. In this study, we investigated …

Cytokines, growth factors, and other locally produced mediators play key roles in the
regulation of disease progression. During liver fibrosis, these mediators orchestrate the …

Pancreatic ductal adenocarcinoma (PDAC) is the deadliest tumor due to its highly abundant
tumor stroma. Pancreatic stellate cells (PSCs) are considered precursor cells of cancer …