Nonalcoholic fatty liver disease (NAFLD), recently renamed metabolic-associated fatty liver
disease (MAFLD), is one of the most common causes of liver diseases worldwide. NAFLD is …

Abstract Cucurbitacin B (CuB, C 32 H 46 O 8), the most abundant and active member of
cucurbitacins, which are highly oxidized tetracyclic triterpenoids. Cucurbitacins are widely …

Major depressive disorder (MDD) is a chronic, generally episodic and debilitating disease
that affects an estimated 300 million people worldwide, but its pathogenesis is poorly …

Understanding sex differences in physiology and disease requires the identification of the
molecular agents that cause phenotypic sex differences. Two groups of such agents are …

Cancer immunotherapy is a major breakthrough in the history of tumor therapy in the last
decade. Immune checkpoint inhibitors blocking CTLA-4/B7 or PD-1/PD-L1 pathways have …

Parkinson's disease (PD) is a distinctive clinical syndrome with several causes and clinical
manifestations. Aside from an infectious cause, PD is a rapidly developing neurological …

The c-Myc signaling is a new emerging target in cancer therapy. Activation of c-Myc
signaling leads to cancer growth and invasion in vitro and in vivo. The stability of c-Myc can …

The recent discovery of vast non-coding RNA-based regulatory networks that can be easily
modulated by nucleic acid-based drugs has opened numerous new therapeutic possibilities …

Simple Summary Meat quality and human-health-related indexes are important traits in beef
cattle breeding. Intramuscular fat content (IMF) is a major meat quality trait that influences …

Simple Summary Long non-coding RNAs (LncRNAs) are non-protein coding molecules
longer than 200 nucleotides. They play essential roles in normal cell function and …