The Notch pathway represents a highly conserved signaling network with essential roles in
regulation of key cellular processes and functions, many of which are critical for …

Idiopathic Pulmonary Fibrosis (IPF) is characterized by injury and loss of lung epithelial
cells, accumulation of fibroblasts/myofibroblasts and abnormal remodeling of the lung …

Angiogenesis: a process of generation of new blood vessels has been proved to be
necessary for sustained tumor growth and cancer progression. Inhibiting angiogenesis …

The phenotypic transformation of hepatic myofibroblasts (MFs) is involved in the whole
process of the progression and regression of liver fibrosis. Notch signaling has been …

Idiopathic pulmonary fibrosis (IPF) is a devastating and fatal disease and characterized by
increased deposition of extracellular matrix proteins and scar formation in the lung, resulting …

Tissue fibrosis can lead to organ dysfunction, patient morbidity, and mortality. Adipose-
derived Stromal/stem Cells (ASCs) represent a potential therapeutic. Immediately following …

Nintedanib (NDN), a tyrosine kinase inhibitor, has been shown to have anti-tumor, anti-
inflammatory, and anti-fibrotic effects in several reports. We investigated the protective …

Notch signaling pathway is involved in the regulation of cell fate, differentiation, proliferation,
and apoptosis in development and disease. Previous studies suggest the importance of …

Objective The aim of this study was to investigate the prophylactic effect and some
mechanisms of action of triterpene acids of loquat (TAL) on bleomycin A5-induced …

Rationale: The differentiation of fibroblasts into myofibroblasts is a cardinal feature of
idiopathic pulmonary fibrosis (IPF). The transcription factor Yin Yang 1 (YY1) plays a role in …