The opioid system consists of three receptors, mu, delta, and kappa, which are activated by
endogenous opioid peptides processed from three protein precursors, proopiomelanocortin …

Attention-deficit/hyperactivity disorder, ADHD, is a common and highly heritable
neuropsychiatric disorder that is seen in children and adults. Although heritability is …

Suicide and related behaviors are complex phenomena associated with different risk factors.
Although most individuals who display suicidal behavior do not have a history of early-life …

Cadherins are Ca2+-dependent cell-cell adhesion molecules that play critical roles in
animal morphogenesis. Various cadherin-related molecules have also been identified …

As heritability is high in attention-deficit/hyperactivity disorder (ADHD), genetic factors must
play a significant role in the development and course of this disorder. In recent years a large …

Cadherins mediate cell–cell adhesion but are also involved in intracellular signaling
pathways associated with neuropsychiatric disease. Most of the∼ 100 cadherins that are …

Despite aggressive efforts to contain it, methamphetamine use disorder continues to be
major public health problem; and with generic behavioral therapies still the mainstay of …

Abstract The Allen Brain Atlas, a Web-based, genome-wide atlas of gene expression in the
adult mouse brain, was an experiment on a massive scale. The development of the atlas …

Nearly half of the people suffering from schizophrenia also present with a lifetime history of
substance use disorders (SUD), a rate that is much higher than the one seen among …

Drug addiction is a common brain disorder that is extremely costly to the individual and to
society. Genetics contributes significantly to vulnerability to this disorder, but identification of …