ATP-binding cassette (ABC) transporters mediate the ATP-driven translocation of structurally
and mechanistically distinct substrates against steep concentration gradients. Among the …

Over the past 60 years, chemotherapeutic agents that target thymidylate biosynthesis and
the enzyme thymidylate synthase (TS) have remained among the most-successful drugs …

This review summarizes the biology of the major facilitative membrane transporters, the
reduced folate carrier (RFC)(Solute Carrier 19A1) and the proton-coupled folate transporter …

Mammalians are devoid of autonomous biosynthesis of folates and hence must obtain them
from the diet. Reduced folate cofactors are B9-vitamins which play a key role as donors of …

Our current understanding of the mechanisms of action of antitumor agents and the precise
mechanisms underlying drug resistance is that these two processes are directly linked …

Cutaneous T-cell lymphomas (CTCLs) are a heterogeneous and relatively rare family of
extranodal non-Hodgkin's lymphomas (NHL) that are primarily localized to the skin. Most …

Pteridines are aromatic compounds formed by fused pyrazine and pyrimidine rings. Many
living organisms synthesize pteridines, where they act as pigments, enzymatic cofactors, or …

Patients with relapsed or refractory peripheral T-cell lymphoma display a dismal prognosis
and their therapy represents an unmet medical need, as the best treatment strategy is yet to …

Pralatrexate is a novel antifolate approved in the USA for the treatment of relapsed or
refractory peripheral T‐cell lymphoma. To assess its safety, efficacy, and pharmacokinetics …

Cancer is a second leading cause of death after heart attack, in developing as well as
undeveloped countries. It is caused by unregulated growth and metastasis of the abnormal …