Given that hypoxia is a persistent physiological feature of many different solid tumors and a
key driver for cancer malignancy, it is thought to be a major target in cancer treatment …

Squamous cell carcinoma of the head and neck (SCCHN) is among the most prevalent
cancer types worldwide. Despite multimodal therapeutic approaches that include surgical …

Tumor starvation by depleting intratumoral glucose has been validated as a promising
therapeutic strategy to combat cancer. However, inadequate oxygenation in hypoxic …

Head and neck cancer is a malignant tumour with a high mortality rate characterized by late
diagnosis, high recurrence and metastasis rates, and poor prognosis. Head and neck …

Background Cancer management faces multiple obstacles, including resistance to current
therapeutic approaches. In the face of challenging microenvironments, cancer cells adapt …

Purpose Cancer cells, despite stemming from the own cells of their host, usually elicit an
immune response. This response usually enables elimination of cancer at its earliest stages …

Hypoxia is a common feature of solid tumors that contributes to angiogenesis, invasiveness,
metastasis, altered metabolism and genomic instability. As hypoxia is a major actor in tumor …

Rationale: Tumor energy metabolism has been a well-appreciated target of cancer therapy;
however, the metabolism change of cancer cells between oxidative phosphorylation and …

Tumour vascularisation is vital for cancer sustainment representing not only the main source
of nutrients and oxygen supply but also an escape route for single or clustered cancer cells …

Introduction The tumor microenvironment (TME) of glioblastoma (GB) is characterized by an
increased infiltration of immunosuppressive cells that attenuate the antitumor immune …