Oxidative stress‐related mechanisms in schizophrenia pathogenesis and new treatment perspectives

EA Ermakov, EM Dmitrieva… - Oxidative Medicine …, 2021 - Wiley Online Library
Schizophrenia is recognized to be a highly heterogeneous disease at various levels, from
genetics to clinical manifestations and treatment sensitivity. This heterogeneity is also …

Immune system abnormalities in schizophrenia: an integrative view and translational perspectives

EA Ermakov, MM Melamud, VN Buneva… - Frontiers in …, 2022 - frontiersin.org
The immune system is generally known to be the primary defense mechanism against
pathogens. Any pathological conditions are reflected in anomalies in the immune system …

Intravenous immunoglobulins as immunomodulators in autoimmune diseases and reproductive medicine

T Velikova, M Sekulovski, S Bogdanova, G Vasilev… - Antibodies, 2023 - mdpi.com
Intravenous administration of immunoglobulins has been routinely used for more than 60
years in clinical practice, developed initially as replacement therapy in immunodeficiency …

Essential protective role of catalytically active antibodies (Abzymes) with redox antioxidant functions in animals and humans

AS Tolmacheva, GA Nevinsky - International Journal of Molecular …, 2022 - mdpi.com
During the life of aerobic organisms, the oxygen resulting from numerous reactions is
converted into reactive oxygen species (ROS). Many ROS are dangerous due to their high …

Natural IgG against S-protein and RBD of SARS-CoV-2 do not bind and hydrolyze DNA and are not autoimmune

AM Timofeeva, SE Sedykh, EA Ermakov… - International Journal of …, 2022 - mdpi.com
Since the onset of the COVID-19 pandemic, numerous publications have appeared
describing autoimmune pathologies developing after a coronavirus infection, with several …

Natural antibodies produced in vaccinated patients and COVID-19 convalescents recognize and hydrolyze oligopeptides corresponding to the S-protein of SARS-CoV …

AM Timofeeva, SE Sedykh, TA Sedykh, GA Nevinsky - Vaccines, 2023 - mdpi.com
The S-protein is the major antigen of the SARS-CoV-2 virus, against which protective
antibodies are generated. The S-protein gene was used in adenoviral vectors and mRNA …

Catalase Activity of IgGs of Patients Infected with SARS-CoV-2

AS Tolmacheva, MK Onvumere, SE Sedykh… - International Journal of …, 2023 - mdpi.com
Coronavirus disease (COVID-19), caused by the SARS-CoV-2 coronavirus, leads to various
manifestations of the post-COVID syndrome, including diabetes, heart and kidney disease …

A systemic review of intravenous immunoglobulin G treatment in women with recurrent implantation failures and recurrent pregnancy losses

W Saab, S Seshadri, C Huang, L Alsubki… - American Journal of …, 2021 - Wiley Online Library
Over the last few decades, the advancement in reproductive technologies and protocols to
improve embryo quality through culture techniques and genetic testing to eliminate …

Identification of Antibody-Mediated Hydrolysis Sites of Oligopeptides Corresponding to the SARS-CoV-2 S-Protein by MALDI-TOF Mass Spectrometry

AM Timofeeva, SE Sedykh, PS Dmitrenok… - International Journal of …, 2023 - mdpi.com
Antibodies recognizing RBD and the S-protein have been previously demonstrated to be
formed in humans after SARS-CoV-2 infection and vaccination with the Sputnik V …

Natural catalytic IgGs hydrolyzing histones in schizophrenia: Are they the link between humoral immunity and inflammation?

EA Ermakov, DA Parshukova, GA Nevinsky… - International journal of …, 2020 - mdpi.com
Schizophrenia is known to be accompanied not only with an imbalance in the
neurotransmitter systems but also with immune system dysregulation and chronic low-grade …