Incidence of antidepressant discontinuation symptoms: a systematic review and meta-analysis

J Henssler, Y Schmidt, U Schmidt, G Schwarzer… - The Lancet …, 2024 - thelancet.com
Background Antidepressant discontinuation symptoms are becoming an increasingly
important part of clinical practice, but the incidence of antidepressant discontinuation …

Clinical practice guideline recommendations on tapering and discontinuing antidepressants for depression: a systematic review

A Sørensen, K Juhl Jørgensen… - Therapeutic advances …, 2022 - journals.sagepub.com
Background: Tapering and discontinuing antidepressants are important aspects of the
management of patients with depression and should therefore be considered in clinical …

Effects of escitalopram on synaptic density in the healthy human brain: a randomized controlled trial

A Johansen, S Armand, P Plavén-Sigray… - Molecular …, 2023 - nature.com
Selective serotonin reuptake inhibitors (SSRIs) are widely used for treating neuropsychiatric
disorders. However, the exact mechanism of action and why effects can take several weeks …

Withdrawing from SSRI antidepressants: advice for primary care

EG Palmer, S Sornalingam, L Page… - British Journal of General …, 2023 - bjgp.org
BACKGROUND All major classes of antidepressants can cause a withdrawal syndrome
when removed. 1 Withdrawal is common, experienced by 56% of those stopping a selective …

Glutamatergic abnormalities in the pregenual anterior cingulate cortex in obsessive-compulsive disorder using magnetic resonance spectroscopy: A controlled study

E Kosová, D Pajuelo, D Greguš, M Brunovský… - Psychiatry Research …, 2023 - Elsevier
In this study, we utilized proton magnetic resonance spectroscopy (MRS) to understand the
role of glutamate (Glu), glutamine (Gln), and gamma-aminobutyric acid (GABA) of OCD …

The Association of Antidepressants in Late Pregnancy with Postpartum Hemorrhage: Systematic Review of Controlled Observational Studies

WV Bobo, KM Moore, HK Betcher… - Journal of Child and …, 2024 - liebertpub.com
Introduction: Despite advances in obstetric care, postpartum hemorrhage (PPH) is a leading
cause of maternal mortality worldwide. Prior reviews of studies published through 2016 …

Incidence and risk factors of antidepressant withdrawal symptoms: a meta-analysis and systematic review

MM Zhang, X Tan, YB Zheng, N Zeng, Z Li… - Molecular …, 2024 - nature.com
Antidepressants are among the most extensively prescribed psychotropic drugs worldwide.
Discontinuation induced withdrawal symptoms have been reported for almost all …

Evaluating lumateperone for its use in treating depressive episodes associated with bipolar I or II disorder in adults

H Abuelazm, OH Elsayed… - Expert Review of …, 2023 - Taylor & Francis
Introduction Lumateperone is a novel antipsychotic medication that has recently received
approval by the United States Food and Drug Administration for treatment of major …

Clinical benefits of vortioxetine 20 mg/day in patients with major depressive disorder

MC Christensen, RS McIntyre, M Adair, I Florea… - CNS …, 2023 - cambridge.org
BackgroundVortioxetine has demonstrated dose-dependent efficacy in patients with major
depressive disorder (MDD), with the greatest effect observed with vortioxetine 20 mg/day …

[HTML][HTML] Dose-response effects of selective serotonin reuptake inhibitor monotherapy for the treatment of depression: systematic review of reviews and meta-narrative …

CF Johnson, M Maxwell, B Williams, N Dougall… - BMJ …, 2022 - ncbi.nlm.nih.gov
Objective To assess and clarify the relations between selective serotonin reuptake inhibitor
(SSRI) dose efficacy, acceptability (early treatment discontinuation (dropouts)), and …