Aging is the main risk factor for vascular disease and ensuing cardiovascular and
cerebrovascular events, the leading causes of death worldwide. In a progressively aging …

Mitochondria play a key role in both health and disease. Their function is not limited to
energy production but serves multiple mechanisms varying from iron and calcium …

A new study published by the journal Aging & Disease reported that intravenous
administration of clinical-grade human mesenchymal stem cells (MSCs) into patients with …

Metformin, a drug widely used for treating diabetes, can prolong the lifespan in several
species. Metformin also has the promise to slow down age‐related cognitive impairment …

A common hallmark of age‐dependent neurodegenerative diseases is an impairment of
adult neurogenesis. Wingless‐type mouse mammary tumor virus integration site (Wnt)/β …

An increase in life expectancy in developed countries has led to a surge of chronic aging-
related diseases. In the last few decades, several studies have provided evidence of the …

The outbreak of coronavirus disease 2019 (COVID-19) pandemic is quickly spreading all
over the world. This virus, which is called SARS-CoV-2, has infected tens of thousands of …

The aim of this review is to critically analyze promises and limitations of pharmacological
inducers of autophagy against protein misfolding-associated neurodegeneration. Effective …

Osteoarthritis (OA) is a chronic, debilitating joint disease characterized by progressive
destruction of articular cartilage. For a long time, OA has been considered as a degenerative …

The brain interstitial fluid (ISF) and the cerebrospinal fluid (CSF) cushion and support the
brain cells. The ISF occupies the brain interstitial system (ISS), whereas the CSF fills the …