Fluoroorganic chemistry has become essential in the evolution of many different but
interconnected research fields. These include the development of new materials with a …

Procreation is essential for survival of species. Not surprisingly, complex neuronal networks
have evolved to mediate the diverse internal and external environmental inputs that regulate …

Prurigo nodularis is a chronic skin condition characterized by severely pruritic nodules that
cause a profound negative impact on quality of life. The second article in this 2-part …

The timely secretion of gonadal sex steroids is essential for the initiation of puberty, the
postpubertal maintenance of secondary sexual characteristics and the normal perinatal …

The neurokinin 1 receptor (NK‐1R) is the main receptor for the tachykinin family of peptides.
Substance P (SP) is the major mammalian ligand and the one with the highest affinity. SP is …

Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

Background Chronic pruritus is a global clinical problem with a high impact on the quality of
life and lack of specific therapies. It is an excruciating and frequent symptom of eg uncurable …

Context: Mutations in TAC3 and TACR3 (encoding neurokinin B and its receptor) have been
identified in Turkish patients with idiopathic hypogonadotropic hypogonadism (IHH), but …

Human genetics indicate that kisspeptin and neurokinin B (NKB) signaling are necessary for
generating pulsatile LH release and therefore for initiation of puberty and maintaining …

Abstract Mu-Opioid Receptors (MORs) are well-known for participating in analgesia,
sedation, drug addiction, and other physiological functions. Although MORs have been …