Rationale Repeated injections of cocaine cause blunted responses to acute cocaine
challenge-induced increases in the expression of immediate early genes (IEGs). Objectives …

Prolyl oligopeptidase (POP) is a serine endopeptidase that hydrolyses proline-containing
peptides shorter than 30-mer, including many bioactive peptides. The distribution of POP in …

Neurokinin B (NKB) was recently identified as a key regulator of reproduction in mammals
and fish. Fish were found to possess a specific novel neurokinin termed NKF. To study the …

Obtaining maximal sensitivity of nano UHPLC-MS/MS methods is primordial to quantify
picomolar concentrations of neuropeptides in microdialysis samples. Since aspecific …

Synaptotagmin 9 (SYT9) is a tandem C2 domain Ca2+ sensor for exocytosis in
neuroendocrine cells; its function in neurons remains unclear. Here, we show that, in mixed …

Pancreatic cancer is the fourth leading cause of cancer related-death for both men and
women and the 1-and 5-year relative survival rates are 25% and 6%, respectively. Thus, it is …

Recent evidence suggests that neurokinin B (NKB), a member of the neurokinin (tachykinin)
peptide family, plays a pivotal role in gonadotropin-releasing hormone (GnRH) pulse …

Ifosfamide is an alkylating antineoplastic drug used in chemotherapy, but it is also detected
in wastewater. Here, the objectives were to (1) determine teratogenic, cardiotoxic, and …

Tachykinins (TKs) are small peptides widely distributed in the central and peripheral
nervous systems where they act as neurotransmitters. Potent and selective TKs antagonists …

Pruritus, the most common symptom in dermatology, is an innate response capable of
protecting skin against irritants. Nonetheless, when it lasts more than six weeks it is …