Recent advances have greatly improved our understanding of the molecular mechanisms
behind atherosclerosis pathogenesis. However, there is still a need to systematize this data …

Septic shock currently represents one of the main causes of mortality in critical patient units
with an increase in its incidence in recent years, and it is also associated with a high burden …

Background: ERK5 (extracellular signal-regulated kinase 5) is a dual kinase transcription
factor containing an N-terminal kinase domain and a C-terminal transcriptional activation …

Rationale: Aging in the heart is a gradual process, involving continuous changes in
cardiovascular cells, including cardiomyocytes (CMs), namely cellular senescence. These …

OBJECTIVES: To describe risk factors for major cardiovascular events in adults following
hospital discharge after sepsis. DESIGN: Population-based cohort study. SETTING: Ontario …

Infections caused by multi-drug-resistant bacteria in patients with chronic diseases have
been associated with high mortality and morbidity. While few reports have evaluated …

Background: Practice patterns and outcomes associated with the use of oral anticoagulation
for arterial thromboembolism prevention following a hospitalization with new-onset atrial …

Whereas aging is a whole-organism process, senescence is a cell mechanism that can be
triggered by several stimuli. There is increasing evidence that critical conditions activate cell …

Sepsis-induced cardiac injury represents a major clinical challenge, amplifying the urgency
for effective therapeutic interventions. This study aimed to delve into the individual and …

Introduction Serum lactate is a potentially valuable biomarker for risk assessment for
patients with sepsis, as hyperlactatemia is associated with elevated short-term mortality …