[HTML][HTML] Lp-PLA2 silencing ameliorates inflammation and autophagy in nonalcoholic steatohepatitis through inhibiting the JAK2/STAT3 pathway

J Yao, Y Zhao - PeerJ, 2023 - peerj.com
Background Nonalcoholic steatohepatitis (NASH), a common cause of liver-related
morbidity and mortality worldwide, is characterized by inflammation and hepatocellular …

Maternal PBDE exposure disrupts gut microbiome and promotes hepatic proinflammatory signaling in humanized PXR-transgenic mouse offspring over time

S Kim, H Li, Y Jin, J Armad, H Gu, S Mani… - Toxicological …, 2023 - academic.oup.com
Developmental exposure to the persistent environmental pollutant, polybrominated diphenyl
ethers (PBDEs), is associated with increased diabetes prevalence. The microbial tryptophan …

Long-term dietary exposure to 2, 2′, 4, 4′-tetrabromodiphenyl ether (BDE-47) reduced feeding in common carp (Cyprinus carpio): Via the JAK-STAT signaling …

X Zhang, Y Liu, H Sun, S Chen, P Tang, Q Hu… - Environmental …, 2024 - Elsevier
Polybrominated diphenyl ethers (PBDEs) are widely present in water ecosystems where
they pose a significant threat to aquatic life, but our knowledge about how PBDEs affect …

[HTML][HTML] Glucoregulatory disruption in male mice offspring induced by maternal transfer of endocrine disrupting brominated flame retardants in DE-71

EV Kozlova, BD Chinthirla, AE Bishay… - Frontiers in …, 2023 - frontiersin.org
Introduction Polybrominated diphenyl ethers (PBDEs) are commercially used flame
retardants that bioaccumulate in human tissues, including breast milk. PBDEs produce …

Single-cell transcriptomics unveiled that early life BDE-99 exposure reprogrammed the gut-liver axis to promote a proinflammatory metabolic signature in male mice at …

JJ Lim, M Goedken, Y Jin, H Gu… - Toxicological Sciences, 2024 - academic.oup.com
Polybrominated diphenyl ethers (PBDEs) are legacy flame retardants that bioaccumulate in
the environment. The gut microbiome is an important regulator of liver functions including …

[HTML][HTML] Maternal Supraphysiological Hypercholesterolemia Is Accompanied by Shifts in the Composition and Anti-Atherogenic Functions of Maternal HDL along with …

C Cantin, A Morales, R Serra, SE Illanes, A Leiva - Antioxidants, 2023 - mdpi.com
Background: Maternal physiological hypercholesterolemia (MPH) occurs in pregnancy for a
proper fetal development. When cholesterol increases over the physiological range …

Nervonic acid suppresses MPTP-induced Parkinson's disease in an adult zebrafish model by regulating the MAPK/NF-κB signaling pathway, inflammation, apoptosis …

X Wang, Y Mao, T Liang, Z Li, X Li, X Zhu, F Cao… - Food Bioscience, 2024 - Elsevier
Being a chronic inflammatory condition, Parkinson's disease (PD) can lead to brain damage.
Nervonic acid is one of the most promising bioactive fatty acids, which is believed to be …