Background: Sepsis is a life-threatening condition responsible for up to 20% of all global
deaths. Kidneys are among the most common organs implicated, yet the pathogenesis of …

Sepsis-induced cardiomyopathy (SIC) is a serious complication of sepsis with high mortality
but no effective treatment. The renin angiotensin (Ang) aldosterone system (RAAS) is …

Acute kidney injury (AKI) and diabetes mellitus (DM) are public health problems that cause a
high socioeconomic burden worldwide. In recent years, the landscape of AKI etiology has …

Background There is no available viable treatment for Sepsis-Induced Cardiomyopathy
(SIC), a common sepsis complication with a higher fatality risk. The septic patients showed …

Liver dysfunction in sepsis is a major complication that amplifies multiple organ failure and
increases the risk of death. Inflammation and oxidative stress are the main mediators in the …

OBJECTIVE: Doxorubicin (DOX) is a widely used cytotoxic anthracycline antibiotic
characterized by increased adverse effects that limit its clinical usefulness. Pregnenolone is …

The current experiment aimed to identify the possible protective role of rivastigmine (RIVA)
in gentamicin (GNT)-induced acute kidney injury (AKI) in rats. RIVA was administered in the …

Purpose To evaluate the effect of renin-angiotensin system (RAS) inhibiting medications
prior to admission on the severity of kidney injury in patients presenting with sepsis …

Maintaining a balance between the supply and demand of oxygen is vital for proper organ
function. Most types of acute kidney injury (AKI) are characterized by hypoxia, a state where …

In cases of sepsis, the immune system responds with an uncontrolled release of
proinflammatory cytokines and reactive oxygen species. The lungs, kidneys, and liver are …