Melanoma is the most lethal skin cancer that originates from the malignant transformation of
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …

The mechanistic target of rapamycin complex 1 (mTORC1) signaling hub integrates multiple
environmental cues to modulate cell growth and metabolism. Over the past decade …

Although melanoma is notorious for its high degree of heterogeneity and plasticity,, the
origin and magnitude of cell-state diversity remains poorly understood. Equally, it is unclear …

Cutaneous melanoma is a highly immunogenic malignancy that is surgically curable at early
stages but life-threatening when metastatic. Here we integrate high-plex imaging, 3D high …

An incomplete view of the mechanisms that drive metastasis, the primary cause of cancer-
related death, has been a major barrier to development of effective therapeutics and …

During the past three decades, mice, zebrafish, fruit flies, and Caenorhabditis elegans have
been the primary model organisms used for the study of various biological phenomena …

The common mutation BRAFV600 in primary melanomas activates the mitogen-activated
protein kinase/extracellular-signal-regulated kinase (MAPK/ERK) pathway and the …

Microphthalmia-associated transcription factor (MITF) is an important regulator of
melanogenesis and melanocyte development. Although it has been studied extensively in …

Epithelial‐to‐mesenchymal transition (EMT), a process through which epithelial tumor cells
acquire mesenchymal phenotypic properties, contributes to both metastatic dissemination …

In the light of substantial discoveries in epithelial and hair pigmentation pathophysiology,
this review summarizes the current understanding of skin pigmentation mechanisms …