Catecholamine autotoxicity. Implications for pharmacology and therapeutics of Parkinson disease and related disorders
DS Goldstein, IJ Kopin, Y Sharabi - Pharmacology & therapeutics, 2014 - Elsevier
Several neurodegenerative diseases involve loss of catecholamine neurons—Parkinson
disease is a prototypical example. Catecholamine neurons are rare in the nervous system …
disease is a prototypical example. Catecholamine neurons are rare in the nervous system …
Loss and remodeling of striatal dendritic spines in Parkinson's disease: from homeostasis to maladaptive plasticity?
RM Villalba, Y Smith - Journal of neural transmission, 2018 - Springer
In Parkinson's disease (PD) patients and animal models of PD, the progressive
degeneration of the nigrostriatal dopamine (DA) projection leads to two major changes in …
degeneration of the nigrostriatal dopamine (DA) projection leads to two major changes in …
Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens
Despite abundant expression of DNA methyltransferases (Dnmts) in brain, the regulation
and behavioral role of DNA methylation remain poorly understood. We found that Dnmt3a …
and behavioral role of DNA methylation remain poorly understood. We found that Dnmt3a …
[HTML][HTML] Homeostatic plasticity and STDP: keeping a neuron's cool in a fluctuating world
Spike-timing dependent plasticity (STDP) offers a powerful means of forming and modifying
neural circuits. Experimental and theoretical studies have demonstrated its potential …
neural circuits. Experimental and theoretical studies have demonstrated its potential …
L-DOPA treatment selectively restores spine density in dopamine receptor D2–expressing projection neurons in dyskinetic mice
Background L-3, 4-dihydroxyphenylalanine (L-DOPA)–induced dyskinesia is an
incapacitating complication of L-DOPA therapy that affects most patients with Parkinson's …
incapacitating complication of L-DOPA therapy that affects most patients with Parkinson's …
[HTML][HTML] Rapid target-specific remodeling of fast-spiking inhibitory circuits after loss of dopamine
AH Gittis, GB Hang, ES LaDow, LR Shoenfeld… - Neuron, 2011 - cell.com
In Parkinson's disease (PD), dopamine depletion alters neuronal activity in the direct and
indirect pathways and leads to increased synchrony in the basal ganglia network. However …
indirect pathways and leads to increased synchrony in the basal ganglia network. However …
L-DOPA oppositely regulates synaptic strength and spine morphology in D1 and D2 striatal projection neurons in dyskinesia
Dopamine depletion in Parkinson's disease (PD) produces dendritic spine loss in striatal
medium spiny neurons (MSNs) and increases their excitability. However, the synaptic …
medium spiny neurons (MSNs) and increases their excitability. However, the synaptic …
Pallidostriatal projections promote β oscillations in a dopamine-depleted biophysical network model
VL Corbit, TC Whalen, KT Zitelli, SY Crilly… - Journal of …, 2016 - Soc Neuroscience
In the basal ganglia, focused rhythmicity is an important feature of network activity at certain
stages of motor processing. In disease, however, the basal ganglia develop amplified …
stages of motor processing. In disease, however, the basal ganglia develop amplified …
[HTML][HTML] Dopamine triggers the maturation of striatal spiny projection neuron excitability during a critical period
Neural circuits are formed and refined during childhood, including via critical changes in
neuronal excitability. Here, we investigated the ontogeny of striatal intrinsic excitability. We …
neuronal excitability. Here, we investigated the ontogeny of striatal intrinsic excitability. We …
[HTML][HTML] Spike-timing-dependent plasticity mediated by dopamine and its role in Parkinson's disease pathophysiology
Parkinson's disease (PD) is a multi-systemic neurodegenerative brain disorder. Motor
symptoms of PD are linked to the significant dopamine (DA) loss in substantia nigra pars …
symptoms of PD are linked to the significant dopamine (DA) loss in substantia nigra pars …