[HTML][HTML] Striatal synaptic adaptations in Parkinson's disease
The striatum is densely innervated by mesencephalic dopaminergic neurons that modulate
acquisition and vigor of goal-directed actions and habits. This innervation is progressively …
acquisition and vigor of goal-directed actions and habits. This innervation is progressively …
LRRK2 phosphorylation of Rab GTPases in Parkinson's disease
SR Pfeffer - FEBS letters, 2023 - Wiley Online Library
Rab GTPases comprise a large family of conserved GTPases that are critical regulators of
the secretory and endocytic pathways. The human genome encodes~ 65 Rabs that localize …
the secretory and endocytic pathways. The human genome encodes~ 65 Rabs that localize …
The role of Smo-Shh/Gli signaling activation in the prevention of neurological and ageing disorders
Sonic hedgehog (Shh) signaling is an essential central nervous system (CNS) pathway
involved during embryonic development and later life stages. Further, it regulates cell …
involved during embryonic development and later life stages. Further, it regulates cell …
Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain
Activating LRRK2 mutations cause Parkinson's disease, and pathogenic LRRK2 kinase
interferes with ciliogenesis. Previously, we showed that cholinergic interneurons of the …
interferes with ciliogenesis. Previously, we showed that cholinergic interneurons of the …
Alterations in neurotransmitter co-release in Parkinson's disease
K Barcomb, CP Ford - Experimental Neurology, 2023 - Elsevier
Parkinson's disease is a neurological disorder characterized by degeneration of midbrain
dopamine neurons, which results in numerous adaptations in basal ganglia circuits …
dopamine neurons, which results in numerous adaptations in basal ganglia circuits …
A cell therapy approach based on iPSC-derived midbrain organoids for the restoration of motor function in a Parkinson's disease mouse model
CL Fu, BC Dong, X Jiang, D Li, J Yao - Heliyon, 2024 - cell.com
Parkinson's disease (PD) is a neurodegenerative disease characterized by the
degeneration of dopaminergic (DA) neurons in the substantia nigra and loss of DA …
degeneration of dopaminergic (DA) neurons in the substantia nigra and loss of DA …
Intercellular communication in the central nervous system as deduced by chemical neuroanatomy and quantitative analysis of images: Impact on neuropharmacology
In the last decades, new evidence on brain structure and function has been acquired by
morphological investigations based on synergic interactions between biochemical anatomy …
morphological investigations based on synergic interactions between biochemical anatomy …
D1/D5 inverse agonists restore striatal cholinergic interneuron physiology in dyskinetic mice
RM Paz, AM Stahl, L Rela, MG Murer… - Movement …, 2022 - Wiley Online Library
Background In advanced stages of Parkinson's disease (PD), dyskinesia and motor
fluctuations become seriously debilitating and therapeutic options become scarce. Aberrant …
fluctuations become seriously debilitating and therapeutic options become scarce. Aberrant …
Effects of curcumin to counteract levodopa-induced toxicity in zebrafish
P Briñez-Gallego, DG da Costa Silva… - Journal of Toxicology …, 2023 - Taylor & Francis
Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor
dysfunction due to the death of dopaminergic neurons in the substantia nigra pars …
dysfunction due to the death of dopaminergic neurons in the substantia nigra pars …
Developmental pathways linked to the vulnerability of adult midbrain dopaminergic neurons to neurodegeneration
N Prakash - Frontiers in Molecular Neuroscience, 2022 - frontiersin.org
The degeneration of dopaminergic and other neurons in the aging brain is considered a
process starting well beyond the infantile and juvenile period. In contrast to other dopamine …
process starting well beyond the infantile and juvenile period. In contrast to other dopamine …