Molecular Mechanism of Pancreatic and Salivary Gland Fluid and HCO3− Secretion
Fluid and HCO3− secretion is a vital function of all epithelia and is required for the survival of
the tissue. Aberrant fluid and HCO3− secretion is associated with many epithelial diseases …
the tissue. Aberrant fluid and HCO3− secretion is associated with many epithelial diseases …
CFTR function and prospects for therapy
JR Riordan - Annu. Rev. Biochem., 2008 - annualreviews.org
Mutations in the gene coding for the cystic fibrosis transmembrane conductance regulator
(CFTR) epithelial anion channel cause cystic fibrosis (CF). The multidomain integral …
(CFTR) epithelial anion channel cause cystic fibrosis (CF). The multidomain integral …
Airway surface liquid pH regulation in airway epithelium current understandings and gaps in knowledge
M Zajac, E Dreano, A Edwards, G Planelles… - International journal of …, 2021 - mdpi.com
Knowledge on the mechanisms of acid and base secretion in airways has progressed
recently. The aim of this review is to summarize the known mechanisms of airway surface …
recently. The aim of this review is to summarize the known mechanisms of airway surface …
Airway gland structure and function
JH Widdicombe, JJ Wine - Physiological reviews, 2015 - journals.physiology.org
Submucosal glands contribute to airway surface liquid (ASL), a film that protects all airway
surfaces. Glandular mucus comprises electrolytes, water, the gel-forming mucin MUC5B …
surfaces. Glandular mucus comprises electrolytes, water, the gel-forming mucin MUC5B …
Physiology of epithelial chloride and fluid secretion
RA Frizzell, JW Hanrahan - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Epithelial salt and water secretion serves a variety of functions in different organ systems,
such as the airways, intestines, pancreas, and salivary glands. In cystic fibrosis (CF), the …
such as the airways, intestines, pancreas, and salivary glands. In cystic fibrosis (CF), the …
Abnormal surface liquid pH regulation by cultured cystic fibrosis bronchial epithelium
RD Coakley, BR Grubb, AM Paradiso… - Proceedings of the …, 2003 - National Acad Sciences
Cystic fibrosis (CF) transmembrane conductance regulator (CFTR)-dependent airway
epithelial bicarbonate transport is hypothesized to participate in airway surface liquid pH …
epithelial bicarbonate transport is hypothesized to participate in airway surface liquid pH …
The characterization of the human cell line Calu-3 under different culture conditions and its use as an optimized in vitro model to investigate bronchial epithelial …
In this study we have investigated the effects of different cell culture conditions on the Calu-3
epithelial cell model. Calu-3 cells were cultured in media A-MEM at the air–liquid (A–L) or …
epithelial cell model. Calu-3 cells were cultured in media A-MEM at the air–liquid (A–L) or …
Cystic fibrosis: lessons from the sweat gland
PM Quinton - Physiology, 2007 - journals.physiology.org
Lessons from the sweat gland on cystic fibrosis (CF) began long before modern medicine
became a science. In European folklore, the curse that “a child that taste salty when kissed …
became a science. In European folklore, the curse that “a child that taste salty when kissed …
Therapeutic potential of KCa3.1 blockers: recent advances and promising trends
H Wulff, NA Castle - Expert review of clinical pharmacology, 2010 - Taylor & Francis
The Ca2+-activated K+ channel KCa3. 1 regulates membrane potential and calcium
signaling in erythrocytes, activated T and B cells, macrophages, microglia, vascular …
signaling in erythrocytes, activated T and B cells, macrophages, microglia, vascular …
Airways in cystic fibrosis are acidified: detection by exhaled breath condensate
S Tate, G MacGregor, M Davis, JA Innes, AP Greening - Thorax, 2002 - thorax.bmj.com
Background: The loss of cystic fibrosis transmembrane conductance regulator (CFTR)
mediated chloride conductance does not fully explain the diverse pathologies evident in …
mediated chloride conductance does not fully explain the diverse pathologies evident in …