Osteosarcoma, with poor survival after metastasis, is considered the most common primary
bone cancer in adolescents. Notwithstanding the efforts of researchers, its five-year survival …

Osteosarcoma is a primary malignant tumor that tends to threaten children and adolescents,
and the 5-year event-free survival rate has not improved significantly in the past three …

Objective Osteosarcoma (OS) is a common bone malignancy with poor prognosis. We
aimed to investigate the relationship between cuproptosis-related lncRNAs (CRLncs) and …

Hypoxia is an environmental stressor that is instigated by low oxygen availability. It fuels the
progression of solid tumors by driving tumor plasticity, heterogeneity, stemness and genomic …

The physiological state of the tumor microenvironment (TME) plays a central role in cancer
development due to multiple universal features that transcend heterogeneity and niche …

Background Osteosarcoma is the most common bone cancer, mainly occurring in children
and adolescents, among which distant metastasis (DM) still leads to a poor prognosis …

Ferroptosis is associated with the prognosis and therapeutic responses of patients with
various cancers. LncRNAs are reported to exhibit antitumor or oncogenic functions …

Background The tumor microenvironment (TME) has a central role in the oncogenesis of
osteosarcomas. The composition of the TME is essential for the interaction between tumor …

Pancreatic cancer (PACA), which is characterized by an immunosuppressive nature,
remains one of the deadliest malignancies worldwide. Aberrant DNA methylation (DNAm) …

Hypoxia-induced decrease in cisplatin (CDDP) sensitivity in human osteosarcoma (OS) is a
significant obstacle to effective chemotherapy. Recently, mitophagy has been shown to be …