Advancing islet transplantation: from engraftment to the immune response
The promise and progress of islet transplantation for treating type 1 diabetes has been
challenged by obstacles to patient accessibility and long-term graft function that may be …
challenged by obstacles to patient accessibility and long-term graft function that may be …
[HTML][HTML] Intra-islet endothelial cell and β-cell crosstalk: Implication for islet cell transplantation
S Narayanan, G Loganathan… - World journal of …, 2017 - ncbi.nlm.nih.gov
The intra-islet microvasculature is a critical interface between the blood and islet endocrine
cells governing a number of cellular and pathophysiological processes associated with the …
cells governing a number of cellular and pathophysiological processes associated with the …
Transplantation of human islets without immunosuppression
B Ludwig, A Reichel, A Steffen… - Proceedings of the …, 2013 - National Acad Sciences
Transplantation of pancreatic islets is emerging as a successful treatment for type-1
diabetes. Its current stringent restriction to patients with critical metabolic lability is justified …
diabetes. Its current stringent restriction to patients with critical metabolic lability is justified …
Improvement of islet function in a bioartificial pancreas by enhanced oxygen supply and growth hormone releasing hormone agonist
B Ludwig, A Rotem, J Schmid… - Proceedings of the …, 2012 - National Acad Sciences
Islet transplantation is a feasible therapeutic alternative for metabolically labile patients with
type 1 diabetes. The primary therapeutic target is stable glycemic control and prevention of …
type 1 diabetes. The primary therapeutic target is stable glycemic control and prevention of …
Clinical and experimental pancreatic islet transplantation to striated muscle: establishment of a vascular system similar to that in native islets
G Christoffersson, J Henriksnäs, L Johansson… - Diabetes, 2010 - Am Diabetes Assoc
OBJECTIVE Curing type 1 diabetes by transplanting pancreatic islets into the liver is
associated with poor long-term outcome and graft failure at least partly due to inadequate …
associated with poor long-term outcome and graft failure at least partly due to inadequate …
Mitigating hypoxic stress on pancreatic islets via in situ oxygen generating biomaterial
MM Coronel, R Geusz, CL Stabler - Biomaterials, 2017 - Elsevier
A major obstacle in the survival and efficacy of tissue engineered transplants is inadequate
oxygenation, whereby unsupportive oxygen tensions result in significant cellular dysfunction …
oxygenation, whereby unsupportive oxygen tensions result in significant cellular dysfunction …
Co-transplantation of mesenchymal stem cells maintains islet organisation and morphology in mice
CL Rackham, PC Chagastelles, NB Nardi… - Diabetologia, 2011 - Springer
Aims/hypothesis Recent studies have shown that mesenchymal stem cells (MSCs) secrete
several factors that improve survival and function of transplanted islets. Implantation of islets …
several factors that improve survival and function of transplanted islets. Implantation of islets …
Increased numbers of low-oxygenated pancreatic islets after intraportal islet transplantation
R Olsson, J Olerud, U Pettersson, PO Carlsson - Diabetes, 2011 - Am Diabetes Assoc
OBJECTIVE No previous study has measured the oxygenation of intraportally transplanted
islets, although recent data suggest that insufficient engraftment may result in hypoxia and …
islets, although recent data suggest that insufficient engraftment may result in hypoxia and …
Bioengineered human pseudoislets form efficiently from donated tissue, compare favourably with native islets in vitro and restore normoglycaemia in mice
Y Yu, A Gamble, R Pawlick, AR Pepper, B Salama… - Diabetologia, 2018 - Springer
Aims/hypothesis Islet transplantation is a treatment option that can help individuals with type
1 diabetes become insulin independent, but inefficient oxygen and nutrient delivery can …
1 diabetes become insulin independent, but inefficient oxygen and nutrient delivery can …
The novel NADPH oxidase 4 inhibitor GLX351322 counteracts glucose intolerance in high-fat diet-treated C57BL/6 mice
E Anvari, P Wikström, E Walum, N Welsh - Free radical research, 2015 - Taylor & Francis
In type 2 diabetes, it has been proposed that pancreatic beta-cell dysfunction is promoted by
oxidative stress caused by NADPH oxidase (NOX) overactivity. Five different NOX enzymes …
oxidative stress caused by NADPH oxidase (NOX) overactivity. Five different NOX enzymes …